98911-39-8

Upstream product

• 186581-53-3 diazomethane 
• 98911-38-7 2-<2-(2,5-Dioxo-1-pyrrolidinyl)phenyl>essigsaeure 
• 123-56-8 Succinimide 
• 57486-69-8 methyl 2-(2-bromophenyl)acetate 
• 3740-52-1 2-(2-nitrophenyl)acetic acid 
• 98911-33-2 2-(2-Nitrophenyl)essigsaeure-tert-butylester 
• 98911-36-5 2-<2-(2,5-Dioxo-1-pyrrolidinyl)phenyl>essigsaeure-tert-butylester 
• 98911-35-4 N-<2-(tert-Butoxycarbonylmethyl)phenyl>succinamsaeure 
• 98911-34-3 2-(2-Aminophenyl)essigsaeure-tert-butylester 
• 74-88-4 methyl iodide 

Downstream Products

• 90163-15-8 (+/-)-2-Brom-2-<2-(2,5-dioxo-1-pyrrolidinyl)phenyl>essigsaeure-methylester 

Relevant academic research and scientific papers

A new route to quinolone and indole skeletones via ketone- and ester-imide cyclodehydration reactions

Ketone-imide cyclodehydration reactions of aromatic succinimide and phthalimide (7, 8) have afforded quinolone acids (11, 12). Further transformation of the acids provided the corresponding esters (13, 14) and vinylogous urethanes (9, 10). Similarly, ester-imide cyclodehydration reactions of aromatic imide esters (19, 20) have afforded indole acids (23, 24).

MITOMYCIN ANTIBIOTICS: SYNTHESIS OF 9a-FUNCTIONALIZED MITOSANES

Two closely related rapid entries into the mitosane ring system are described which allow for structural modifications.First examples of a hydroxylation and a methoxylation at the 9a-position of mitosanes are reported.