98948-95-9

Basic information

• Product Name: 6-BROMO-4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID
• Synonyms: OTAVA-BB BB7110950773;6-BROMO-4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID;AURORA 19699;BUTTPARK 21\09-50;4-Hydroxy-6-broMoquinoline-3-carboxylic acid
• CAS NO: 98948-95-9
• Molecular Formula: C₁₀H₆BrNO₃
• Molecular Weight: 268.06
• EINECS: -0
• Product Categories: CHIRAL CHEMICALS
• Mol File: 98948-95-9.mol
• Article Data: 21

Chemical Properties

• Boiling Point: 412.069 °C at 760 mmHg
• Flash Point: 203.013 °C
• Appearance: /
• Density: 1.805 g/cm³
• Vapor Pressure: 1.58E-07mmHg at 25°C
• Refractive Index: 1.667
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: 6-BROMO-4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 6-BROMO-4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID(98948-95-9)
• EPA Substance Registry System: 6-BROMO-4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID(98948-95-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 98948-95-9(Hazardous Substances Data)

Usage

Uses

It is used as a pharmaceutical intermediate.

InChI:InChI=1/C10H6BrNO3/c11-5-1-2-8-6(3-5)9(13)7(4-12-8)10(14)15/h1-4H,(H,12,13)(H,14,15)

Upstream product

• 122794-99-4 6-bromo-4-hydroxyquinoline-3-carboxylic acid ethyl ester 
• 106-40-1 4-bromo-aniline 
• 19056-84-9 diethyl 2-[(p-tolylamino)methylidene]malonate 
• 101937-44-4 diethyl 2-((4-bromophenylamino)methylene)malonate 
• 79607-23-1 ethyl 6-bromo-4-oxo-1,4-dihydro-quinoline-3-carboxylate 

Downstream Products

• 145369-94-4 6-bromoquinolin-4-ol 
• 145369-94-4 6-bromo-3-quinolinecarboxylic acid-4-ol 
• 65340-70-7 6-bromo-4-chloroquinoline 
• 916812-64-1 6-ethenyl-4-quinolinecarbonitrile 
• 916812-31-2 6-bromo-N-methyl-4-quinolinamine 
• 916812-25-4 4-hydroxy-6-quinolinecarbaldehyde 
• 676256-25-0 4-chloroquinoline-6-carbaldehyde 

Relevant articles and documents

PAPD5 INHIBITORS AND METHODS OF USE THEREOF

The present application provides compounds that are PAPD5 inhibitors and are useful in treating a variety of conditions such as cancer, telomere diseases, and aging-related and other degenerative disorders.

6-bromo-4-chloroquinoline preparation method

The invention discloses a 6-bromo-4-chloroquinoline preparation method. 4-bromaniline, ethyl propiolate, phosphorus trichloride and the like are used as raw materials to obtain a target product 6-bromo-4-chloroquinoline through three-step reaction. The 6-bromo-4-chloroquinoline preparation method is convenient and simple in operation and environment friendly, the comprehensive yield is 70% or above and remarkably increased as compared with existing yield which is 26-42%, existing medicine production cost is sharply reduced, and the 6-bromo-4-chloroquinoline preparation method is suitable for industrial mass production.

Combination of mTOR inhibitors and P13-kinase inhibitors, and uses thereof

The present invention provides for a method for treating a disease condition associated with PI3-kinase α and/or mTOR in a subject. In another aspect, the invention provides for a method for treating a disease condition associated with PI3-kinase α and/or mTOR in a subject. In yet another aspect, a method of inhibiting phosphorylation of both Akt (S473) and Akt (T308) in a cell is set forth.