98966-14-4

Usage

Uses

Used in Pharmaceutical Industry:
2,2'-dihydroxy-5,5'-diacetyldiaminebiphenyl is used as a peroxidase substrate for the determination of peroxidase activities. It is particularly useful in the development of diagnostic assays and research studies related to peroxidase enzymes.
Used in Chemical Synthesis:
2,2'-dihydroxy-5,5'-diacetyldiaminebiphenyl can be used as a starting material or intermediate in the synthesis of various organic compounds, including pharmaceuticals, agrochemicals, and other specialty chemicals. Its unique structure and functional groups make it a versatile building block for chemical reactions.
Used in Analytical Chemistry:
2,2'-dihydroxy-5,5'-diacetyldiaminebiphenyl can be employed as a chromogenic or fluorogenic reagent in analytical chemistry. Its ability to change color or fluorescence upon reaction with specific analytes makes it a valuable tool for the detection and quantification of various chemical species.

Upstream product

• 103-90-2 4-acetaminophenol 

Relevant academic research and scientific papers

Enzyme Immobilized Magnetic Nanoparticles for in-line capillary electrophoresis and drug biotransformation studies: Application to paracetamol

Enzyme Immobilized Magnetic Nanoparticles (EMNPs) were injected and magnetically retained, as a microreactor, in the capillary of a capillary electrophoresis (CE) setup with UV detection. The enzyme horseradish peroxidase (HRP) was chemically immobilized onto commercially available magnetic 300 nm diameter nanoparticles. Paracetamol (acetaminophen: N-acetyl-p-aminophenol), a common analgesic drug, was used as model drug compound. The enzymatic reaction was studied in-line by CE in 12.5 mM phosphate buffer pH 7.4 containing 20 mg/ml sulfated-β-cyclodextrin and 0.1 mM hydrogen peroxide. By means of the developed setup, the apparent Michaelis Menten constant between HRP and acetaminophen (APAP) was determined as Kmapp = 53±5 μM. This approach was found to be of interest for enzyme kinetics studies with short time resolution condition. Based on our results and from the literature data, it was possible to infer that the in-line generated product was an APAP dimer. Higher enzyme immobilized beads loading in the CE setup generated the APAP dimer with two additional minor peaks likely attributing to APAP trimer and tetramer. N-acetyl-p-benzoquinone imine (NAPQI) was not generated during APAP short time migration through the in-line microreactor.

Preparation of bisaryl derivative, bisaryl derivative and application

The invention relates to a bisaryl derivative and a preparation method and application thereof. A structure of the bisaryl derivative is as shown in a formula (II). The invention provides the bisarylderivative, and a method for synthesizing the bisaryl derivative by copper-catalyzed aryl coupling, an operation process is simple, raw materials are commercialized and easily available, the catalystis cheap and easy to obtain and environment-friendly, reaction conditions are mild, site selectivity is high, the reaction is efficient, and the bisaryl derivative can be prepared only by one step. Inaddition, the reaction uses a surfactant as an auxiliary solvent, so that the reaction can be carried out in an aqueous solution, and the need for an acid and an organic solvent of a traditional bisaryl coupling reaction is overcome.

Cobalt(II)-porphyrin-catalyzed aerobic oxidation: Oxidative coupling of phenols

The first example of the cobalt-porphyrin-catalyzed aerobic oxidative coupling of phenols through oxidative C-H functionalization has been developed. In the presence of T(p-OMe)PPCo and Na2CO3, the oxidative coupling of phenols with different substituents proceeded smoothly with O 2 as a terminal oxidant to give the corresponding biaryl compounds in satisfactory yields. The biaryl derivatives are important in the area of pharmaceuticals and as ligands in metal catalysis. Preliminary mechanistic studies of this oxidative coupling reaction are also reported. The T(p-OMe)PPCo-catalyzed oxidative coupling of phenols was developed for the synthesis of biphenols. This reaction features low catalyst loadings, mild reaction conditions, and operational simplicity. Preliminary mechanistic studies were conducted.

Injectable liquid formulation of paracetamol

The invention relates to a novel injectable liquid formulation of paracetamol, comprising an aqueous solvent, a buffer agent with a pKa between 4.5 and 6.5, an isotonic agent and the dimer of paracetamol of formula (I), a method for preparation of said formulation and the use of said dimer for the stabilisation of a liquid paracetamol pharmaceutical formulation.