98966-14-4

Basic information

• Product Name: 2,2'-dihydroxy-5,5'-diacetyldiaminebiphenyl
• Synonyms: 2,2'-dihydroxy-5,5'-diacetyldiaminebiphenyl;AcetaMinophen DiMer;N,N'-(6,6'-Dihydroxy[1,1'-biphenyl]-3,3'-diyl)bisacetaMide;ParacetaMol DiMer IMpurity;AcetaMide, N,N'-(6,6'-dihydroxy[1,1'-biphenyl]-3,3'-diyl)bis-;N,N-(6,6'-dihydroxybiphenyl-3,3'-diyl)diacetamide
• CAS NO: 98966-14-4
• Molecular Formula: C16H16N2O4
• Molecular Weight: 300.3092
• Product Categories: Aromatics;Impurities;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 98966-14-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 642.2°Cat760mmHg
• Flash Point: 342.2°C
• Appearance: /
• Density: 1.379g/cm³
• Storage Temp.: Refrigerator
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 8.96±0.43(Predicted)
• CAS DataBase Reference: 2,2'-dihydroxy-5,5'-diacetyldiaminebiphenyl(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2'-dihydroxy-5,5'-diacetyldiaminebiphenyl(98966-14-4)
• EPA Substance Registry System: 2,2'-dihydroxy-5,5'-diacetyldiaminebiphenyl(98966-14-4)

Safety Data

• Hazardous Substances Data: 98966-14-4(Hazardous Substances Data)

Usage

Chemical Properties

Purple Brown Solid

Uses

Acetaminophen Dimer is an oxidatively couple dimer of Acetaminaphen (A161220). Acetaminophen Dimer along with other p-acetamidophenol analogs were used to determine peroxidase activities.

Upstream product

• 103-90-2 4-acetaminophenol 

Relevant articles and documents

Studies on fluorometric analysis of phenol derivatives. II. Fluorometric determination of paracetamol ('acetaminophen') I (Japanese)

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Preparation of bisaryl derivative, bisaryl derivative and application

The invention relates to a bisaryl derivative and a preparation method and application thereof. A structure of the bisaryl derivative is as shown in a formula (II). The invention provides the bisarylderivative, and a method for synthesizing the bisaryl derivative by copper-catalyzed aryl coupling, an operation process is simple, raw materials are commercialized and easily available, the catalystis cheap and easy to obtain and environment-friendly, reaction conditions are mild, site selectivity is high, the reaction is efficient, and the bisaryl derivative can be prepared only by one step. Inaddition, the reaction uses a surfactant as an auxiliary solvent, so that the reaction can be carried out in an aqueous solution, and the need for an acid and an organic solvent of a traditional bisaryl coupling reaction is overcome.

Injectable liquid formulation of paracetamol

The invention relates to a novel injectable liquid formulation of paracetamol, comprising an aqueous solvent, a buffer agent with a pKa between 4.5 and 6.5, an isotonic agent and the dimer of paracetamol of formula (I), a method for preparation of said formulation and the use of said dimer for the stabilisation of a liquid paracetamol pharmaceutical formulation.