1425794-19-9

Basic information

• Product Name: 2-(2,4-dimethylphenylsulfanyl)phenyl carbamic acid tert-butyl ester
• Synonyms: 2-(2,4-dimethylphenylsulfanyl)phenyl carbamic acid tert-butyl ester
• CAS NO: 1425794-19-9
• Molecular Weight: 329.463
• Mol File: 1425794-19-9.mol

Chemical Properties

• CAS DataBase Reference: 2-(2,4-dimethylphenylsulfanyl)phenyl carbamic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2,4-dimethylphenylsulfanyl)phenyl carbamic acid tert-butyl ester(1425794-19-9)
• EPA Substance Registry System: 2-(2,4-dimethylphenylsulfanyl)phenyl carbamic acid tert-butyl ester(1425794-19-9)

Safety Data

• Hazardous Substances Data: 1425794-19-9(Hazardous Substances Data)

Upstream product

• 13616-82-5 2,4-dimethyl-thiophenol 
• 98968-72-0 tert-butyl 2-fluorophenylcarbamate 
• 35426-69-8 o-chlorobenzenecarbamic acid tert-butyl ester 
• 78839-75-5 2-bromo-N-(tert-butoxycarbonyl)aniline 
• 24424-99-5 di-tert-butyl dicarbonate 
• 615-36-1 2-bromoaniline 

Downstream Products

• 1019453-85-0 2-(2,4-dimethylphenylsulphanyl)benzeneamine 
• 1425794-20-2 4-(2-(2,4-dimethylphenylthio)phenyl)thiomorpholine-3,5-dione 
• 1425794-21-3 4-(2-(2,4-dimethylphenylthio)phenyl)thiomorpholine 
• 1425794-23-5 4-(2-(2,4-dimethylphenylthio)phenyl)-1-methylthiomorpholin-1-ium tetrafluoroborate 

Relevant articles and documents

A suitable hydrobromidum fertile for method for synthesizing west sandbank industrial production (by machine translation)

The invention provides a novel method for preparing vortioxetine hydrobromide, and belongs to the technical field of medicine synthesis. The method uses 2-fluoroaniline as a starting material to prepare the clinical medicinal vortioxetine hydrobromide by Boc protection, condensation, deprotection condensation, cyclization and other 4 steps of reaction. The method has the advantages of easy obtained raw material, low price, simple synthesis operation, mild reaction condition, easy control, no high pressure, good reaction selectivity, high yield and suitability for industrial production.

Preparation method of anti-depression drug 1-[2-(2,4-dimethylphenylthio)phenyl]piperazine

The invention relates to a preparation method of an anti-depression drug 1-[2-(2,4-dimethylphenylthio)phenyl]piperazine (VI). The method comprises the following steps: condensing an initial raw material 2,4-dimethylthiophenol (I) and t-butyl 2-X halogenated phenyl carbamate (II) to generate t-butyl 2-(2,4-dimethylphenylthioalkyl) phenyl carbamate (III), carrying out Boc group removal on the t-butyl 2-(2,4-dimethylphenylthioalkyl) phenyl carbamate (III) in a proper organic solvent solution of hydrogen chloride to obtain 2-(2,4-dimethylphenylthioalkyl)aniline hydrochloride (IV), and carrying out ring closing on the 2-(2,4-dimethylphenylthioalkyl)aniline hydrochloride (IV) and bis(2-chloroethyl)amine hydrochloride (V) to generate 1-[2-(2,4-dimethylphenylthio)phenyl]piperazine (VI). The preparation method has the advantages of concise technology, economy, environmental protection, and suitableness for industrial production.

PERMANENTLY POSITIVELY CHARGED ANTIDEPRESSANTS

The present invention provides compounds comprising a substructure of below formula 3: or a salt or prodrug thereof and the use of such compounds in treatment of e.g. CNS disorders.