98991-08-3

Basic information

• Product Name: 2-iodo-1-methoxy-3-nitro-benzene
• Synonyms: 2-iodo-1-methoxy-3-nitro-benzene;2-Iodo-3-nitroanisole
• CAS NO: 98991-08-3
• Molecular Formula: C₇H₆INO₃
• Molecular Weight: 279.03
• Product Categories: Anisoles, Alkyloxy Compounds & Phenylacetates;Iodine Compounds;Nitro Compounds
• Mol File: 98991-08-3.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-iodo-1-methoxy-3-nitro-benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-iodo-1-methoxy-3-nitro-benzene(98991-08-3)
• EPA Substance Registry System: 2-iodo-1-methoxy-3-nitro-benzene(98991-08-3)

Safety Data

• Hazardous Substances Data: 98991-08-3(Hazardous Substances Data)

Usage

General Description

2-iodo-1-methoxy-3-nitro-benzene is a chemical compound with the molecular formula C7H6INO3. It is a derivative of benzene with a nitro, methoxy, and iodo group attached to the aromatic ring. This chemical is commonly used in organic synthesis and pharmaceutical research due to its ability to undergo various reactions such as nucleophilic substitution, aromatic electrophilic substitution, and reduction. It is also used as a precursor in the synthesis of various biologically active compounds and pharmaceutical drugs. Additionally, it is important to handle this chemical with caution as it is considered hazardous and can cause skin and eye irritation, as well as potential health risks if ingested or inhaled.

Upstream product

• 603-85-0 2-Amino-3-nitrophenol 
• 554-84-7 meta-nitrophenol 
• 197243-48-4 2-iodo-3-nitrophenol 
• 77-78-1 dimethyl sulfate 
• 74-88-4 methyl iodide 

Downstream Products

• 168105-48-4 C₇₂H₇₀O₁₀ 
• 1436417-39-8 C₃₁H₂₇NO₅ 
• 1436417-41-2 C₄₀H₃₆BrNO₆ 
• 1436417-40-1 C₄₀H₃₇NO₆ 
• 1258849-43-2 3-(2-methoxy-6-nitrophenyl)-1-methyl-1H-pyrrole-2,5-dione 
• 98991-10-7 3-methoxy-1,2-diiodobenzene 

Relevant articles and documents

Synthetic method for optically pure double-helix oligomeric tetra-benzocyclooctene substances

The invention discloses a synthetic method for optically pure double-helix oligomeric tetra-benzocyclooctene substances. The synthetic method comprises the following steps: (1) carrying out oxidative cross-coupling on diiodo dimethoxy biphenyl (51) and 2,2',6,6'-biphenyl tetrabromide (97) to obtain 1,16-dibromo-8,9-dimethoxy tetra-benzocyclooctene (96); (2) splitting the compound (96), thus obtaining optically pure (S, S)-96 and (R, R)-96; (3) taking the compound (96) as a raw material, synthesizing an intermediate (116) containing 6 benzene rings; (4) splitting the intermediate (116) to obtain (M)-116 and (P)-116; (5) making the optically pure (S, S)-96 and (M)-116 reacted to obtain target products, namely (M) -117, (M)-149 and (M)-150; and/or: making the (R, R)-96 and (P)-116 reacted to obtain target products, namely (P)-117, (P)-149 and (P)-150.

Total synthesis of indole-3-acetonitrile-4-methoxy-2-C-β-d- glucopyranoside. Proposal for structural revision of the natural product

Indole-3-acetonitrile-4-methoxy-2-C-β-d-glucopyranoside (1), a novel C-glycoside from Isatis indigotica with important cytotoxic activity, has been prepared in ten steps from ethynyl-β-C-glycoside 3 and 2-iodo-3-nitrophenyl acetate 6. Key steps in the synthesis include a Sonogashira coupling and a CuI-mediated indole formation. NMR spectroscopic data for synthetic 1 differs from that reported for the natural product. A revised structure for the natural product, containing an alternate carbohydrate substituent, is proposed. The Royal Society of Chemistry 2012.

Chiral biphenylamide derivative: An efficient organocatalyst for the enantioselective synthesis of α-hydroxy phosphonates

The aldol reactions of α-keto phosphonates and aldehydes were facilitated by an axially chiral biphenylprolinamide under mild conditions, affording the synthetically and pharmaceutically useful products in high yields and excellent enantioselectivities.