197243-48-4Relevant articles and documents
Substituted Fused Heteroaromatic Tricyclic Compounds as Kinase Inhibitors and The Use Thereof
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Paragraph 0166; 0203, (2021/05/07)
The disclosure relates to substituted fused heteroaromatic tricyclic compounds and the use thereof. Specifically, the disclosure provides compounds of the following Formula I: or a pharmaceutically acceptable salt or prodrug thereof, wherein A1
Synthetic method for optically pure double-helix oligomeric tetra-benzocyclooctene substances
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Paragraph 0033; 0034; 0035, (2017/07/31)
The invention discloses a synthetic method for optically pure double-helix oligomeric tetra-benzocyclooctene substances. The synthetic method comprises the following steps: (1) carrying out oxidative cross-coupling on diiodo dimethoxy biphenyl (51) and 2,2',6,6'-biphenyl tetrabromide (97) to obtain 1,16-dibromo-8,9-dimethoxy tetra-benzocyclooctene (96); (2) splitting the compound (96), thus obtaining optically pure (S, S)-96 and (R, R)-96; (3) taking the compound (96) as a raw material, synthesizing an intermediate (116) containing 6 benzene rings; (4) splitting the intermediate (116) to obtain (M)-116 and (P)-116; (5) making the optically pure (S, S)-96 and (M)-116 reacted to obtain target products, namely (M) -117, (M)-149 and (M)-150; and/or: making the (R, R)-96 and (P)-116 reacted to obtain target products, namely (P)-117, (P)-149 and (P)-150.
Total synthesis of dictyodendrins B and E, and formal synthesis of dictyodendrin C
Tao, Pengyu,Liang, Jingjing,Jia, Yanxing
, p. 5735 - 5748 (2014/11/07)
A full account of the concise total syntheses of dictyodendrins B and E, and the formal synthesis of dictyodendrin C are described. A palladium-catalysed Larock indole synthesis was used to form the highly substituted indole core, and a palladium-mediated
