Welcome to LookChem.com Sign In|Join Free

CAS

  • or

499-12-7

Post Buying Request

499-12-7 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

499-12-7 Usage

Identification

▼▲ CAS.No.:? 499-12-7? FL.No.:? 8.033 FEMA.No.:? 2010 NAS.No.:? 2010 CoE.No.:? 33 EINECS.No.:? 207-877-0? JECFA.No.:? 627

Description

Aconitic acid has pleasant, winey, acid taste; almost odorless. Aconitic acid of the trans-configuration can be isolated during the processing of sugarcane by precipitating it as the calcium salt from cane syrup or molasses. The concentration in molasses ranges from 1.8 to 2.5%. Aconitic acid may be synthesized from citric acid by dehydration with sulfuric acid or by catalytic dehydration. The cis-configuration is somewhat unstable and is readily rearranged to the trans form by heating. Trans-aconitic acid is decarboxylated to itaconic acid by heating to 180°F. The cis form occurs in plant and animal tissues as a metabolic intermediate in the Krebs cycle during the isomerization of citric acid to isocitric acid by the action of enzyme aconitase.

Regulatory Status

CoE: Approved. Bev.: 2 ppm; Food: 15 ppm FDA: 21 CFR: 184.1007, 582.60 FDA (other): n/a JECFA: ADI: Acceptable. No safety concern at current levels of intake when used as a flavoring agent (1999).

Usage

Reported uses (ppm): (FEMA, 1994) ▼▲ Food Category? Usual? Max.? Alcoholic beverages? 15 20 Baked goods? 8.94 25.21 Frozen dairy? 5.55 8.54 Nonalcoholic beverages? 1.64 3.36 Soft candy? 22.39 31.2

Natural occurrence

Reported found in beet root, sugarcane, the leaves and tubers of Aconitum napellus, and other natural products (Pelargonium species).

Chemical Properties

Aconitic acid has pleasant, winey, acid taste; almost odorless. Aconitic acid of the trans-configuration can be isolated during the processing of sugarcane by precipitating it as the calcium salt from cane syrup or molasses. The concentration in molasses ranges from 1.8 to 2.5%. Aconitic acid may be synthesized from citric acid by dehydration with sulfuric acid or by catalytic dehydration. The cis-configuration is somewhat unstable and is readily rearranged to the trans form by heating. Trans-aconitic acid is decarboxylated to itaconic acid by heating to 180°F. The cis form occurs in plant and animal tissues as a metabolic intermediate in the Krebs cycle during the isomerization of citric acid to isocitric acid by the action of enzyme aconitase

Occurrence

Reported found in beet root, sugarcane, the leaves and tubers of Aconitum napellus, and other natural products (Pelargonium species).

Uses

Aconitic Acid is a flavoring substance which occurs in the leaves and tubers of aconitum napellus l. And other ranunculaceae. Transaconitic acid can be isolated during sugar cane processing, by precipitation as the calcium salt from cane sugar or molasses. It may be synthesized by sulfuric acid dehydration of citric acid but not by the methanesulfonic acid method. It is used in a maximum level, as served, of 0.003% for baked goods, 0.002% for alcoholic beverages, 0.0015% for frozen dairy products, 0.0035% for soft candy, and 0.0005% or less for all other food categories.

Definition

ChEBI: A tricarboxylic acid that is prop-1-ene substituted by carboxy groups at positions 1, 2 and 3.

Preparation

By dehydration of citric acid with concentrated H2SO4: Aconitic acid prepared by this or other methods has the transconfiguration; the cis-isomer is little known. Trans-aconitic acid can be isolated during sugarcane processing by precipitation as the calcium salt from cane sugar or molasses.

Taste threshold values

Taste characteristics at 25 ppm: nutty, vegetative, musty and slightly caramellic

Check Digit Verification of cas no

The CAS Registry Mumber 499-12-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,9 and 9 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 499-12:
(5*4)+(4*9)+(3*9)+(2*1)+(1*2)=87
87 % 10 = 7
So 499-12-7 is a valid CAS Registry Number.
InChI:InChI=1/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)

499-12-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name aconitic acid

1.2 Other means of identification

Product number -
Other names (E)-and (Z)-propene-1,2,3-tricarboxylic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Food additives -> Flavoring Agents
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:499-12-7 SDS

499-12-7Synthetic route

2-amino-propane-1,2,3-tricarboxylic acid
86883-54-7

2-amino-propane-1,2,3-tricarboxylic acid

1 propene 1,2,3 tricarboxylic acid
499-12-7

1 propene 1,2,3 tricarboxylic acid

Conditions
ConditionsYield
With 2-nitrophenyl bromide; copper(l) chloride In cyclohexane at 65 - 115℃; for 7h; Temperature; Concentration;81%
(2,5-dioxo-2,5-dihydro-pyrrol-3-yl)-acetic acid

(2,5-dioxo-2,5-dihydro-pyrrol-3-yl)-acetic acid

furan-2,3,5(4H)-trione pyridine (1:1)

furan-2,3,5(4H)-trione pyridine (1:1)

1 propene 1,2,3 tricarboxylic acid
499-12-7

1 propene 1,2,3 tricarboxylic acid

triethyl O-acetylcitrate
77-89-4

triethyl O-acetylcitrate

1 propene 1,2,3 tricarboxylic acid
499-12-7

1 propene 1,2,3 tricarboxylic acid

Conditions
ConditionsYield
at 250 - 280℃; ueberdestilliert die Essigsaeure, dann verseift man mit konz.Salzsaeure und destilliert diese unter vermindertem Druck ab;
propene-1,1,2,3,3-pentacarboxylic acid pentamethyl ester
872823-24-0

propene-1,1,2,3,3-pentacarboxylic acid pentamethyl ester

1 propene 1,2,3 tricarboxylic acid
499-12-7

1 propene 1,2,3 tricarboxylic acid

Conditions
ConditionsYield
beim Verseifen;
sodium diethylmalonate
996-82-7, 34727-00-9, 73177-21-6

sodium diethylmalonate

diethyl ether
60-29-7

diethyl ether

acetylenedicarboxylic acid diethyl ester
762-21-0

acetylenedicarboxylic acid diethyl ester

A

1 propene 1,2,3 tricarboxylic acid
499-12-7

1 propene 1,2,3 tricarboxylic acid

B

methylammonium carbonate
15719-64-9, 15719-76-3, 97762-63-5

methylammonium carbonate

sodium diethylmalonate
996-82-7, 34727-00-9, 73177-21-6

sodium diethylmalonate

acetylenedicarboxylic acid diethyl ester
762-21-0

acetylenedicarboxylic acid diethyl ester

1 propene 1,2,3 tricarboxylic acid
499-12-7

1 propene 1,2,3 tricarboxylic acid

Conditions
ConditionsYield
verseift man mit Barytwasser, so resultiert eine Saeure, die in freie Zustande sofort in Kohlendioxyd und Aconitsaeure zerfaellt;
sodium diethylmalonate
996-82-7

sodium diethylmalonate

acetylenedicarboxylic acid diethyl ester
762-21-0

acetylenedicarboxylic acid diethyl ester

1 propene 1,2,3 tricarboxylic acid
499-12-7

1 propene 1,2,3 tricarboxylic acid

citric acid
77-92-9

citric acid

A

citraconic acid
498-23-7

citraconic acid

B

1 propene 1,2,3 tricarboxylic acid
499-12-7

1 propene 1,2,3 tricarboxylic acid

Conditions
ConditionsYield
With hydrogen iodide
citric acid
77-92-9

citric acid

1 propene 1,2,3 tricarboxylic acid
499-12-7

1 propene 1,2,3 tricarboxylic acid

Acetylenedicarboxylic acid
142-45-0

Acetylenedicarboxylic acid

A

1 propene 1,2,3 tricarboxylic acid
499-12-7

1 propene 1,2,3 tricarboxylic acid

B

oxalic acid
144-62-7

oxalic acid

Conditions
ConditionsYield
With potassium carbonate
citric acid
77-92-9

citric acid

A

diethyl 3-hydroxypentanedioate
638-18-6

diethyl 3-hydroxypentanedioate

B

Mesaconic acid
498-24-8

Mesaconic acid

C

1 propene 1,2,3 tricarboxylic acid
499-12-7

1 propene 1,2,3 tricarboxylic acid

D

2-methylenesuccinic acid
97-65-4

2-methylenesuccinic acid

E

citraconic acid anhydride
616-02-4

citraconic acid anhydride

F

itaconic acid anhydride
2170-03-8

itaconic acid anhydride

Conditions
ConditionsYield
With Sn/Pb solder at 150 - 210℃;
2,6-dihydroxy-isonicotinic acid amide
14533-64-3

2,6-dihydroxy-isonicotinic acid amide

KOH-solution

KOH-solution

1 propene 1,2,3 tricarboxylic acid
499-12-7

1 propene 1,2,3 tricarboxylic acid

Conditions
ConditionsYield
at 150℃; im Rohr;
hydrogenchloride
7647-01-0

hydrogenchloride

citrazinic acid
99-11-6

citrazinic acid

A

1 propene 1,2,3 tricarboxylic acid
499-12-7

1 propene 1,2,3 tricarboxylic acid

B

ammonia
7664-41-7

ammonia

Conditions
ConditionsYield
at 180℃; im Rohr;
2-ethoxycarbonylmethyl-4,5-dioxo-tetrahydro-furan-2,3-dicarboxylic acid diethyl ester
95800-58-1

2-ethoxycarbonylmethyl-4,5-dioxo-tetrahydro-furan-2,3-dicarboxylic acid diethyl ester

alcoholic KOH-solution

alcoholic KOH-solution

A

1 propene 1,2,3 tricarboxylic acid
499-12-7

1 propene 1,2,3 tricarboxylic acid

B

oxalic acid
144-62-7

oxalic acid

C

acetic acid
64-19-7

acetic acid

hydrogenchloride
7647-01-0

hydrogenchloride

citric acid
77-92-9

citric acid

1 propene 1,2,3 tricarboxylic acid
499-12-7

1 propene 1,2,3 tricarboxylic acid

Conditions
ConditionsYield
at 140℃;
at 140 - 150℃;
tetrachloromethane
56-23-5

tetrachloromethane

phosphoric acid
86119-84-8, 7664-38-2

phosphoric acid

citric acid
77-92-9

citric acid

1 propene 1,2,3 tricarboxylic acid
499-12-7

1 propene 1,2,3 tricarboxylic acid

Conditions
ConditionsYield
katalytische Dehydratisierung;
hydrogen bromide
10035-10-6, 12258-64-9

hydrogen bromide

citric acid
77-92-9

citric acid

1 propene 1,2,3 tricarboxylic acid
499-12-7

1 propene 1,2,3 tricarboxylic acid

citric acid
77-92-9

citric acid

66 percent H2SO4

66 percent H2SO4

1 propene 1,2,3 tricarboxylic acid
499-12-7

1 propene 1,2,3 tricarboxylic acid

citric acid
77-92-9

citric acid

H2S2O7

H2S2O7

1 propene 1,2,3 tricarboxylic acid
499-12-7

1 propene 1,2,3 tricarboxylic acid

sulfuric acid
7664-93-9

sulfuric acid

water
7732-18-5

water

citric acid
77-92-9

citric acid

A

1 propene 1,2,3 tricarboxylic acid
499-12-7

1 propene 1,2,3 tricarboxylic acid

B

2-methylenesuccinic acid
97-65-4

2-methylenesuccinic acid

Conditions
ConditionsYield
at 175℃;
hydrogen iodide
10034-85-2

hydrogen iodide

citric acid
77-92-9

citric acid

A

citraconic acid
498-23-7

citraconic acid

B

1 propene 1,2,3 tricarboxylic acid
499-12-7

1 propene 1,2,3 tricarboxylic acid

C

carbon dioxide
124-38-9

carbon dioxide

Acetylenedicarboxylic acid
142-45-0

Acetylenedicarboxylic acid

alcoholic KOH-solution

alcoholic KOH-solution

A

1 propene 1,2,3 tricarboxylic acid
499-12-7

1 propene 1,2,3 tricarboxylic acid

B

oxalic acid
144-62-7

oxalic acid

phosphorus pentachloride
10026-13-8, 874483-75-7

phosphorus pentachloride

citric acid
77-92-9

citric acid

A

hydrogenchloride
7647-01-0

hydrogenchloride

B

1 propene 1,2,3 tricarboxylic acid
499-12-7

1 propene 1,2,3 tricarboxylic acid

C

aconitic acid chloride

aconitic acid chloride

Conditions
ConditionsYield
erhitzt man das Reaktionsprodukt auf 100grad;
sulfuric acid
7664-93-9

sulfuric acid

water
7732-18-5

water

citric acid
77-92-9

citric acid

A

1 propene 1,2,3 tricarboxylic acid
499-12-7

1 propene 1,2,3 tricarboxylic acid

B

carbon dioxide
124-38-9

carbon dioxide

C

acetone
67-64-1

acetone

D

CO

CO

α-cyano-aconitic acid triethyl ester

α-cyano-aconitic acid triethyl ester

1 propene 1,2,3 tricarboxylic acid
499-12-7

1 propene 1,2,3 tricarboxylic acid

Conditions
ConditionsYield
With hydrogenchloride
hydrogenchloride
7647-01-0

hydrogenchloride

3-cyano-propene-1,2,3-tricarboxylic acid triethyl ester

3-cyano-propene-1,2,3-tricarboxylic acid triethyl ester

1 propene 1,2,3 tricarboxylic acid
499-12-7

1 propene 1,2,3 tricarboxylic acid

hydrogenchloride
7647-01-0

hydrogenchloride

propene-1,1,2,3-tetracarboxylic acid tetraethyl ester

propene-1,1,2,3-tetracarboxylic acid tetraethyl ester

1 propene 1,2,3 tricarboxylic acid
499-12-7

1 propene 1,2,3 tricarboxylic acid

Conditions
ConditionsYield
Hydrolysis;
threo-D-isocitric acid
6061-97-8

threo-D-isocitric acid

sulfuric acid
7664-93-9

sulfuric acid

1 propene 1,2,3 tricarboxylic acid
499-12-7

1 propene 1,2,3 tricarboxylic acid

acetylcitric acid anhydride

acetylcitric acid anhydride

1 propene 1,2,3 tricarboxylic acid
499-12-7

1 propene 1,2,3 tricarboxylic acid

Conditions
ConditionsYield
With ethanol; potassium carbonate mit Salzsaeure stark ansaeuern, fuegen Wasser hinzu,entfernen den Alkohol und extrahiert mit Aether;
aconitic acid anhydride of mp: 135 degree

aconitic acid anhydride of mp: 135 degree

1 propene 1,2,3 tricarboxylic acid
499-12-7

1 propene 1,2,3 tricarboxylic acid

Conditions
ConditionsYield
With potassium hydroxide vorsichtige Zersetzung des entstandenen Salzes mit Salzsaeure; unstable form of/the/ aconitic acid;
1 propene 1,2,3 tricarboxylic acid
499-12-7

1 propene 1,2,3 tricarboxylic acid

abietic acid
514-10-3

abietic acid

C26H36O8

C26H36O8

Conditions
ConditionsYield
With sulfate-doped zirconia In acetic acid at 180℃; for 4h; Reagent/catalyst; Temperature; Solvent; Inert atmosphere;93%
dabigatran etexilate
211915-06-9

dabigatran etexilate

1 propene 1,2,3 tricarboxylic acid
499-12-7

1 propene 1,2,3 tricarboxylic acid

3-(((2-(((4-(N'-hexyloxicarbonylcarbamidoyl)phenyl)amino)methyl)-1-methyl-1H-benzimidazol-5-yl)carbonyl)piridin-2-ylamino)propionic acid ethyl ester acotinate

3-(((2-(((4-(N'-hexyloxicarbonylcarbamidoyl)phenyl)amino)methyl)-1-methyl-1H-benzimidazol-5-yl)carbonyl)piridin-2-ylamino)propionic acid ethyl ester acotinate

Conditions
ConditionsYield
In acetone at 20℃; for 3h;87.7%
methanol
67-56-1

methanol

1 propene 1,2,3 tricarboxylic acid
499-12-7

1 propene 1,2,3 tricarboxylic acid

trimethyl aconitate
20820-77-3

trimethyl aconitate

Conditions
ConditionsYield
With sulfuric acid for 36h; Reflux;85%
methanol
67-56-1

methanol

1 propene 1,2,3 tricarboxylic acid
499-12-7

1 propene 1,2,3 tricarboxylic acid

trimethyl trans-aconitate
4271-99-2

trimethyl trans-aconitate

Conditions
ConditionsYield
With sulfuric acid
With hydrogenchloride
3,5-dihydroxyphenol
108-73-6

3,5-dihydroxyphenol

1 propene 1,2,3 tricarboxylic acid
499-12-7

1 propene 1,2,3 tricarboxylic acid

(1',3',6',8'-tetrahydroxy-5-oxo-5H-spiro[furan-2,9'-xanthen]-4-yl)-acetic acid

(1',3',6',8'-tetrahydroxy-5-oxo-5H-spiro[furan-2,9'-xanthen]-4-yl)-acetic acid

Conditions
ConditionsYield
With sulfuric acid
ethanol
64-17-5

ethanol

1 propene 1,2,3 tricarboxylic acid
499-12-7

1 propene 1,2,3 tricarboxylic acid

1-propene-1,2,3-tricarboxylic acid triethyl ester
68077-28-1

1-propene-1,2,3-tricarboxylic acid triethyl ester

Conditions
ConditionsYield
With sulfuric acid
ethanol
64-17-5

ethanol

1 propene 1,2,3 tricarboxylic acid
499-12-7

1 propene 1,2,3 tricarboxylic acid

Diethyl-3-(ethoxycarbonyl)pent-2-endioat
5349-99-5

Diethyl-3-(ethoxycarbonyl)pent-2-endioat

Conditions
ConditionsYield
With hydrogenchloride
1 propene 1,2,3 tricarboxylic acid
499-12-7

1 propene 1,2,3 tricarboxylic acid

4-chlorophenyldiazonium salt
17333-85-6

4-chlorophenyldiazonium salt

((E)-4-chloro-benzylidene)-succinic acid
46733-89-5

((E)-4-chloro-benzylidene)-succinic acid

Conditions
ConditionsYield
With sodium acetate; copper dichloride nachfolgend Belichten unter Zusatz von wenig Brom;
1 propene 1,2,3 tricarboxylic acid
499-12-7

1 propene 1,2,3 tricarboxylic acid

thieno[2,3-b]thiophene
250-84-0

thieno[2,3-b]thiophene

Conditions
ConditionsYield
With diphosphorus trisulfide bei der Destillation;
1 propene 1,2,3 tricarboxylic acid
499-12-7

1 propene 1,2,3 tricarboxylic acid

cis-aconitic anhydride
6318-55-4

cis-aconitic anhydride

Conditions
ConditionsYield
With acetyl chloride
at 140℃; under 15 - 20 Torr;
With acetic anhydride
With chloroform; acetyl chloride
1 propene 1,2,3 tricarboxylic acid
499-12-7

1 propene 1,2,3 tricarboxylic acid

2,6-dioxo-3,6-dihydro-2H-pyran-4-carboxylic acid
14556-16-2

2,6-dioxo-3,6-dihydro-2H-pyran-4-carboxylic acid

Conditions
ConditionsYield
With chloroform; acetyl chloride
With chloroform; acetic anhydride at 40℃;
1 propene 1,2,3 tricarboxylic acid
499-12-7

1 propene 1,2,3 tricarboxylic acid

hydroxycitric acid
6205-14-7

hydroxycitric acid

Conditions
ConditionsYield
With hypochloric acid anschliessend Behandeln des Reaktionsprodukts mit Kalkmilch;
1 propene 1,2,3 tricarboxylic acid
499-12-7

1 propene 1,2,3 tricarboxylic acid

succinic acid
110-15-6

succinic acid

Conditions
ConditionsYield
durch Einw.von Bacterium succinicum;
1 propene 1,2,3 tricarboxylic acid
499-12-7

1 propene 1,2,3 tricarboxylic acid

A

succinic acid
110-15-6

succinic acid

B

tricarallylic acid
99-14-9

tricarallylic acid

Conditions
ConditionsYield
With bacterium succinicum n.sp; phosphate-buffer
1 propene 1,2,3 tricarboxylic acid
499-12-7

1 propene 1,2,3 tricarboxylic acid

2-methylenesuccinic acid
97-65-4

2-methylenesuccinic acid

Conditions
ConditionsYield
bei der Destillation;
bei der Destillation ensteht zunaechst in Form ihres Anhydrids;
With water at 180℃;
1 propene 1,2,3 tricarboxylic acid
499-12-7

1 propene 1,2,3 tricarboxylic acid

A

2-methylenesuccinic acid
97-65-4

2-methylenesuccinic acid

B

methylammonium carbonate
15719-64-9, 15719-76-3, 97762-63-5

methylammonium carbonate

Conditions
ConditionsYield
Erhitzen ueber die Schmelzpunkt;
1 propene 1,2,3 tricarboxylic acid
499-12-7

1 propene 1,2,3 tricarboxylic acid

propene-1,2,3-tricarbonyl chloride

propene-1,2,3-tricarbonyl chloride

Conditions
ConditionsYield
With phosphorus pentachloride; trichlorophosphate Destillation im Vakuum;
1 propene 1,2,3 tricarboxylic acid
499-12-7

1 propene 1,2,3 tricarboxylic acid

tricarallylic acid
99-14-9

tricarallylic acid

Conditions
ConditionsYield
durch Natriumamalgam;
Durch elektolitische Reduktion von halb mit Natron neutralisierter Aconitsaeure in der Kaelte unter Verwendung einer Quecksilberkathode;
With sodium amalgam bei der Reduktion der Aconitsaeure mit Natriumamalgam entstehende Loesung des Natriumsalzes nach starker Verduennung mit Bleizucker und zerlegt den Niederschlag durch Schwefelwasserstoff;
1 propene 1,2,3 tricarboxylic acid
499-12-7

1 propene 1,2,3 tricarboxylic acid

2-bromo-propane-1,2,3-tricarboxylic acid
110685-61-5

2-bromo-propane-1,2,3-tricarboxylic acid

Conditions
ConditionsYield
With hydrogen bromide at 80℃;
With hydrogen bromide at 100℃;
1 propene 1,2,3 tricarboxylic acid
499-12-7

1 propene 1,2,3 tricarboxylic acid

itaconic acid anhydride
2170-03-8

itaconic acid anhydride

Conditions
ConditionsYield
at 140℃; Erhitzen im Vakuum;
1 propene 1,2,3 tricarboxylic acid
499-12-7

1 propene 1,2,3 tricarboxylic acid

benzene-1,2-diol
120-80-9

benzene-1,2-diol

(4',5'-dihydroxy-5-oxo-5H-spiro[furan-2,9'-xanthen]-4-yl)-acetic acid

(4',5'-dihydroxy-5-oxo-5H-spiro[furan-2,9'-xanthen]-4-yl)-acetic acid

Conditions
ConditionsYield
With tin(IV) chloride at 110℃;
1 propene 1,2,3 tricarboxylic acid
499-12-7

1 propene 1,2,3 tricarboxylic acid

Thiosalicylic acid
147-93-3

Thiosalicylic acid

2-oxo-2H-benzo[4,5]thieno[3,2-b]pyran-4-carboxylic acid

2-oxo-2H-benzo[4,5]thieno[3,2-b]pyran-4-carboxylic acid

Conditions
ConditionsYield
With sulfuric acid at 25℃;
1 propene 1,2,3 tricarboxylic acid
499-12-7

1 propene 1,2,3 tricarboxylic acid

acetyl chloride
75-36-5

acetyl chloride

itaconic acid anhydride
2170-03-8

itaconic acid anhydride

Conditions
ConditionsYield
Erhitzen im Vakuum;
1 propene 1,2,3 tricarboxylic acid
499-12-7

1 propene 1,2,3 tricarboxylic acid

aniline
62-53-3

aniline

3,4-bis-phenylcarbamoyl-crotonic acid

3,4-bis-phenylcarbamoyl-crotonic acid

Conditions
ConditionsYield
With water aconitic acid dianilide of mp: 188-189 degree;
1 propene 1,2,3 tricarboxylic acid
499-12-7

1 propene 1,2,3 tricarboxylic acid

aniline
62-53-3

aniline

(2,5-dioxo-1-phenyl-2,5-dihydro-pyrrol-3-yl)-acetic acid anilide
874497-11-7

(2,5-dioxo-1-phenyl-2,5-dihydro-pyrrol-3-yl)-acetic acid anilide

Conditions
ConditionsYield
at 140℃;

499-12-7Relevant articles and documents

Synthetic method of itaconic acid intermediate 3-carboxy-2-pentene-1,5-diacid

-

Paragraph 0007; 0015; 0016, (2016/11/24)

The invention provides a synthetic method of an itaconic acid intermediate 3-carboxy-2-pentene-1,5-diacid. The synthetic method comprises the following steps: adding 310ml of cyclohexane, 1.3mol of 2-bromo-nitrobenzene solution, 1.6-1.9mol of 3-amino-1,3,5-pentanoic triacid solution and 0.56mol of cuprous chloride to a reaction vessel on which a stirrer, a thermometer and a dropping funnel are installed, controlling the stirring speed at 150-190rpm, raising the temperature of the solution to 110-115 DEG C, reacting for 3-5 hours, reducing the temperature of the solution to 60-65 DEG C, controlling the stirring speed at 200-230rpm, continuously reacting for 90-120 minutes, separating out a solid, carrying out suction filtration, adding the solid to 200ml of oxalic acid solution, stirring the materials for 30-50 minutes, carrying out suction filtration, adopting ethyl acetate for washing and a dehydrating agent for dehydration and carrying out recrystallization in nitromethane, thus obtaining the crystal 3-carboxy-2-pentene-1,5-diacid.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 499-12-7