99-22-9Relevant academic research and scientific papers
Steric influence on hapto interactions in supramolecularly linked thallium dithiocarbamates
Ramalingam, Kuppukkannu,Rizzoli, Corrado,Alexander, Nagarajan
, p. 1329 - 1334 (2013)
Spectral and structural characterization of diallyl and dibenzyl dithiocarbamates of thallium(I) indicated increased thalliocarbon hapto interactions in dibenzyl dithiocarbamate due to increased steric effects. Proton magnetic resonance spectra of the compounds showed that the protons in the vicinity of the thioureide nitrogen are highly deshielded and the corresponding 13C spectra showed large chemical shifts of the thioureide carbons due to decreased electron density. Cyclic voltammetry and bond valence calculations established that the oxidation number of thallium was +1. The Tl-S bond distances in both compounds did not vary significantly. η1-Tl···C(S2) supramolecular interactions were observed in both compounds. A nonclassical S···H bond (2.841 A) was also observed in the dibenzyl compound. Aside from the two noncovalent interactions mentioned, additional hapto interactions such as Tl(1)S2η1Cη 1Cη2C2 and Tl(2)S2η 1Cη3C3 were observed. Both compounds formed polymeric chains through hapto interactions.
Synthesis, characterization, and antibacterial activity of dibenzildithiocarbamate derivates and Ni(II)–Cu(II) coordination compounds
Amaya-Flórez, Andres,Aranaga, Carlos,D'Vries, Richard F.,Ellena, Javier,Flórez-López, Edwin,Macías, Mario,Pastrana-Dávila, Andrea
, (2021/07/28)
In this work, the study of the synthesis methodology to obtain dibenzylamine derivates as intermediates for the formation of dithicarbamate ligands (DTC) and its coordination compounds was conducted. Four molecules derived from dibenzylamine were synthesized by two methodologies: classical (reflux) and microwave. From these amines, Four dithiocarbamate ligands (DTC): dibenzyldithiocarbamate, N-benzyl-1-(4-methoxyphenyl)dithiocarbamate, N-benzyl-1-(4-chlorophenyl)dithiocarbamate, and N-benzyl-1-(3-nitrophenyl)dithiocarbamate, and eight coordination complexes with general formula [M(DTC)2]nH2O (M= Cu(II) and Ni(II)) were obtained. All the compounds were characterized using different spectroscopic and thermal techniques such as Fourier-transform infrared spectroscopy (FT-IR), ultraviolet–visible spectroscopy (UV–VIS), proton and carbon-13 nuclear magnetic resonance (1H and 13C NMR), thermogravimetric analysis–differential scanning calorimetry (TGA-DSC). Additionally, it was possible to characterize two new crystalline phases of salts through single-crystal X-ray diffraction: dibenzyl ammonium nitrate and N-benzyl-1-(3-nitrophenyl)ammonium chloride. Additionally, microbial inhibition tests were conducted using the dibenzildithiocarbamate derivates. All DTC compounds showed important activity against Pseudomonas aeruginosa and Staphylococcus aureus but less sensitivity against Escherichia coli and Mycobacterium smegmatis. Among the coordination compounds, only [Cu(N-benzyl-1-(3-nitrophenyl)dithiocarbamate)2] presented a moderate activity against M. smegmatis mc2 155.
Method for preparing tetraalkyl thiuram disulfide through photocatalytic oxidation
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Paragraph 0095; 0097; 0100; 0102; 0104; 0106; 0108; 0110, (2021/02/13)
The invention relates to a method for preparing tetraalkyl thiuram disulfide by photocatalytic oxidation. The method comprises the following steps: carrying out mixed reaction on secondary amine, carbon disulfide and a catalyst in a medium to generate an intermediate product; and carrying out catalytic oxidation reaction on the intermediate product under illumination to obtain tetraalkyl thiuram disulfide. According to the invention, the method is high in reaction speed and mild in condition, and energy conservation and efficiency improvement are achieved; the used medium and catalyst can be recycled, so that the resource utilization rate is improved; and the method does not produce inorganic salt by-products, and the product has high yield and high purity.
Dithiocarbamation of spiro-aziridine oxindoles: a facile access to C3-functionalised 3-thiooxindoles as apoptosis inducing agents
Bhandari, Sonal,Godugu, Chandraiah,Laxmikeshav, Kritika,Panda, Biswajit,Sakla, Akash P.,Shankaraiah, Nagula,Soni, Jay Prakash
, p. 10622 - 10634 (2021/12/27)
Herein, we report the first dithiocarbamation of spiro-aziridine oxindoles involving regiospecific ring-opening by usingin situgenerated nucleophilic dithiocarbamates as an instant source of sulfur. This approach afforded C3-functionalised-3-thiooxindoles in good to excellent yields with a wide substrate scope under catalyst-free and mild reaction conditions. These compounds were screened for their anticancer activity against a panel of human cancer cell lines, wherein compound3uexhibited significant cytotoxic activity against human lung cancer cells with an IC50value of 4.31 ± 1.88 μM. Phase contrast microscopy as well as different staining assays such as acridine orange/ethidium bromide (AO/EB), DAPI and DCFDA demonstrated the induction of apoptosis in A549 lung cancer cells after treatment with compound3u. In addition, the clonogenic assay and migration assay demonstrated the ability of compound3uto inhibit colony formation and cell migration, respectively, in A549 cells in a dose-dependent manner.
Synthesis and crystal structures of bis(dibenzyl dithiocarbamato)Cu(II) and Ag(I) complexes: Precursors for Cu1.8S and Ag2S nano-photocatalysts
Ajibade, Peter A.,Botha, Nandipha L.,Oluwalana, Abimbola E.,Omondi, Bernard,Sikakane, Berlinda M.
, (2020/07/06)
We report the synthesis and crystal structures of bis(dibenzyl dithiocarbamato) copper(II) and silver(I) complexes and their use as precursors to prepare Cu1.8S and Ag2S nanoparticles. Single crystal analysis of bis(dibenzyl dithiocarbamato)Cu(II) complex consist of a monomeric entity where the two dibenzyl dithiocarbamate ligands form a distorted square planar geometry around the Cu(II) ion. The bis(dibenzyl dithiocarbamato)Ag(I) formed hexameric coordination complex consisting of two distorted hexagonal Ag3S3 rings. The complexes were thermolysed at 220 °C to prepare copper sulphide and silver sulphide nanoparticles. Powder X-ray diffraction (p-XRD) patterns of the copper sulphide nanoparticles were indexed to digenite Cu1.8S, while silver sulphide nanoparticles were confirmed to be acathinite Ag2S. High-resolution transmission electron microscopy (HRTEM) images showed Ag2S nanoparticles with particle size in the range 11.4–27.4 nm while Cu1.8S nanoparticles are semi-spherical in shape with slightly agglomerated particles in the range 6.9–24.0 nm. The as-prepared nanoparticles were used as nano-photocatalysts for the degradation of methylene blue dye (MB) under UV light irradiation with degradation efficiency of 42.52% and 48.39% for Cu1.8S and Ag2S nanoparticles respectively.
