99008-87-4

Basic information

• Product Name: 2-[2-(diethylamino)ethyl]-5-nitro-1,2-dihydropyrazolo[3,4,5-kl]acridin-9-yl 2,2-dimethylpropanoate
• Synonyms: propanoic acid, 2,2-dimethyl-, 2-[2-(diethylamino)ethyl]-1,2-dihydro-5-nitropyrazolo[3,4,5-kl]acridin-9-yl ester
• CAS NO: 99008-87-4
• Molecular Formula: C₂₄H₂₉N₅O₄
• Molecular Weight: 451.5182
• Mol File: 99008-87-4.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 636.1°C at 760 mmHg
• Flash Point: 338.5°C
• Density: 1.256g/cm³
• Vapor Pressure: 4.42E-16mmHg at 25°C
• Refractive Index: 1.634
• CAS DataBase Reference: 2-[2-(diethylamino)ethyl]-5-nitro-1,2-dihydropyrazolo[3,4,5-kl]acridin-9-yl 2,2-dimethylpropanoate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[2-(diethylamino)ethyl]-5-nitro-1,2-dihydropyrazolo[3,4,5-kl]acridin-9-yl 2,2-dimethylpropanoate(99008-87-4)
• EPA Substance Registry System: 2-[2-(diethylamino)ethyl]-5-nitro-1,2-dihydropyrazolo[3,4,5-kl]acridin-9-yl 2,2-dimethylpropanoate(99008-87-4)

Safety Data

• Hazardous Substances Data: 99008-87-4(Hazardous Substances Data)

Usage

Functional Groups

Diethylamino group: Provides basic properties, influencing solubility and reactivity.
Nitro group: Can enhance electron density, affecting reactivity and potentially bioactivity.
Ester functional group: Imparts ester-like properties, such as stability and hydrolysis susceptibility.

Structural Feature

Pyrazolo[3,4,5-kl]acridine ring: A fused bicyclic heterocyclic ring system, contributing to the compound's aromaticity and overall structure.

Attached Moiety

2,2-dimethylpropanoate: Adds steric hindrance and potentially alters the compound's lipophilicity and stability.

Potential Applications

Pharmaceutical or research applications: Due to its complex structure, it could serve as a precursor or intermediate in the synthesis of various chemicals or materials.

Reactivity

Reactivity would depend on the nature of the functional groups and their positioning within the molecule, influencing potential chemical reactions and applications.

Solubility

Solubility characteristics can vary based on the presence of polar or nonpolar groups, impacting its use in different solvents or formulations.

Upstream product

• 99009-49-1 1-chloro-7-hydroxy-4-nitro-9(10H)-acridinone 
• 924-29-8 N-[2-(diethylamino)ethyl]hydrazine 
• 3282-30-2 pivaloyl chloride 
• 99008-65-8 2-[2-(diethylamino)ethyl]-2,6-dihydro-5-nitropyrazolo[3,4,5-kl]acridine-9-ol 
• 99009-51-5 2-Chloro-5-nitro-6-[[4-(phenylmethoxy)phenyl]amino]benzoic acid 
• 99009-50-4 1-chloro-4-nitro-7-(phenylmethoxy)-9(10H)-acridinone 
• 6373-46-2 p-benzyloxyaniline 
• 55775-97-8 2,6-dichloro-3-nitrobenzoic acid 

Relevant articles and documents

2-(Aminoalkyl)-5-nitropyrazoloacridines, a New Class of Anticancer Agents

2-(Aminoalkyl)-5-nitropyrazoloacridines were prepared from substituted anilines via the 1-chloro-4-nitroacridones followed by condensation with hydrazines.Impressive activity was demonstrated for the 9-hydroxy, 9-alkoxy, and 9-acyloxy analogs in vitro on a L1210 leukemia line and in vivo against the P388 leukemia.Advanced studies led to the selection of 3bbb for clinical trial.