99009-49-1

Usage

Uses

Used in Pharmaceutical Industry:
8-Chloro-5-nitro-acridin-2,9-diol is used as a key intermediate in the synthesis of morpholino imidazoacridinone compounds. These compounds have demonstrated potential therapeutic effects in treating various conditions, including inflammatory and demyelinating diseases, as well as cancers. The unique structural features of 8-Chloro-5-nitro-acridin-2,9-diol allow for the development of novel therapeutic agents with improved efficacy and reduced side effects.

Upstream product

• 99009-50-4 1-chloro-4-nitro-7-(phenylmethoxy)-9(10H)-acridinone 
• 55775-97-8 2,6-dichloro-3-nitrobenzoic acid 
• 6373-46-2 p-benzyloxyaniline 
• 99009-51-5 2-Chloro-5-nitro-6-[[4-(phenylmethoxy)phenyl]amino]benzoic acid 
• 50-30-6 2,6-dichlorobenzoic acid 

Downstream Products

• 99008-65-8 2-[2-(diethylamino)ethyl]-2,6-dihydro-5-nitropyrazolo[3,4,5-kl]acridine-9-ol 
• 99008-87-4 2,2-dimethylpropanoic acid 2-[2-(diethylamino)ethyl]-2,6-dihydro-5-nitropyrazolo[3,4,5-kl]acridine-9-yl ester 
• 99008-93-2 Benzoic acid 2-(2-diethylamino-ethyl)-5-nitro-2,6-dihydro-pyrazolo[3,4,5-kl]acridin-9-yl ester 
• 138154-40-2 NCI637992 
• 138154-39-9 5-(2-(diethylamino)ethylamino)-8-hydroxy-6H-imidazo[4,5,1-de]acridin-6-one 
• 138154-38-8 NSC637991 
• 128113-19-9 5-<2-(dimethylamino)ethylamino>-8-hydroxy-6H-<1,2,3>-triazolo<4,5,1-de>acridin-6-one 

Relevant academic research and scientific papers

Structure-activity relationship of novel acridone derivatives as antiproliferative agents

Unlike other DNA topoisomerase II (topo II) inhibitors, our recently identified acridone derivative E17 exerted strong cytotoxic activity by inhibiting topo II without causing topo II degradation and DNA damage, which promoted us to explore more analogues

Novel inhibitors of NRH:Quinone oxidoreductase 2 (NQO2): Crystal structures, biochemical activity, and intracellular effects of imidazoacridin-6-ones

Imidazoacridin-6-ones are shown to be potent nanomolar inhibitors of the enzyme NQO2. By use of computational molecular modeling, a reliable QSAR was established, relating inhibitory potency with calculated binding affinity. Further, crystal structures of

2-(Aminoalkyl)-5-nitropyrazoloacridines, a New Class of Anticancer Agents

2-(Aminoalkyl)-5-nitropyrazoloacridines were prepared from substituted anilines via the 1-chloro-4-nitroacridones followed by condensation with hydrazines.Impressive activity was demonstrated for the 9-hydroxy, 9-alkoxy, and 9-acyloxy analogs in vitro on a L1210 leukemia line and in vivo against the P388 leukemia.Advanced studies led to the selection of 3bbb for clinical trial.

Substituted 1-amino-4-nitro-acridinones and methods of treating bacterial infections and leukemia with them

Substituted 1-amino-4-nitroacridinones, their method of manufacture, pharmaceutical compositions and their use as antibacterial and antitumor agents are herein described.

Pyrazolo[3,4,5-kl]acridine compositions and methods for their production and use

Pyrazolo[3,4,5-kl]acridines are described as antibacterial agents and antitumor agents as well as pharmaceutical compositions and methods for their preparation.