99008-93-2

Upstream product

• 98-88-4 benzoyl chloride 
• 99008-65-8 2-[2-(diethylamino)ethyl]-2,6-dihydro-5-nitropyrazolo[3,4,5-kl]acridine-9-ol 
• 924-29-8 N-[2-(diethylamino)ethyl]hydrazine 
• 99009-51-5 2-Chloro-5-nitro-6-[[4-(phenylmethoxy)phenyl]amino]benzoic acid 
• 99009-50-4 1-chloro-4-nitro-7-(phenylmethoxy)-9(10H)-acridinone 
• 99009-49-1 1-chloro-7-hydroxy-4-nitro-9(10H)-acridinone 
• 6373-46-2 p-benzyloxyaniline 
• 55775-97-8 2,6-dichloro-3-nitrobenzoic acid 

Relevant academic research and scientific papers

2-(Aminoalkyl)-5-nitropyrazoloacridines, a New Class of Anticancer Agents

2-(Aminoalkyl)-5-nitropyrazoloacridines were prepared from substituted anilines via the 1-chloro-4-nitroacridones followed by condensation with hydrazines.Impressive activity was demonstrated for the 9-hydroxy, 9-alkoxy, and 9-acyloxy analogs in vitro on a L1210 leukemia line and in vivo against the P388 leukemia.Advanced studies led to the selection of 3bbb for clinical trial.