99060-14-7

Upstream product

• 64-18-6 formic acid 
• 32687-33-5 3-p-tolyl-2H-azirine 
• 619-41-0 4-(bromoacetyl)toluene 
• 127118-89-2 C₁₁H₁₁NO₃ 

Downstream Products

• 87087-20-5 isoquinoline-7-carboxaldehyde 
• 54004-38-5 7-methyl isoquinoline 
• 102014-89-1 formic acid-(β-hydroxy-4-methyl-phenethylamide) 

Relevant academic research and scientific papers

Self-Catalyzed Rapid Synthesis of N-Acylated/ N-Formylated α-Aminoketones and N-Hydroxymethylated Formamides from 3-Aryl-2 H-Azirines and 2-Me/Ph-3-Aryl-2 H-Azirines

A rapid and effective method has been established for the synthesis of N-acylated α-aminoketone derivatives by the reaction of 3-aryl-2H-azirines and highly substituted 2-Me/Ph-3-aryl-2H-azirines with various carboxylic acids under ambient air within 10 min at room temperature. N-Trifluoroacetylated α-aminoketones with different substituents have been reported in the presence of trifluoroacetic acid. This protocol is equally effective to synthesize N-formylated α-aminoketone and N-hydroxymethylated formamide derivatives.

A Convenient Synthesis of Aminomethyl Ketones (α-Amino Ketones)

Several N,N-diformylaminomethyl ketones 3 were prepared by treating the respective bromomethylketone 1 with sodium diformylamide in acetonitrile at room temperature.This reaction produced from N-formylaminomethyl ketones 4 when ethanol was used as the solvent.One of the formyl groups of N,N-difomylaminomethyl ketones was selectively removed by using a catalytic amount of sodium or potassium hydroxide in alcohol to the corresponding N-formylaminomethyl ketones 4.The formyl groups of both N,N-diformyl- and N-formylaminomethyl ketones could be easily removed by either5percent hydrochloric acid in ethanol or 6N hydrochloric acid to give the corresponding aminomethyl ketone hydrochlorides 5.These reactions are general and give high yield of the products.

A CONVENIENT PREPARATION OF AMINOMETHYL ARYL KETONES AND THEIR DERIVATIVES

A convenient preparation of N-phenacyl diformamides, N-phenacyl formamides and aminomethyl aryl ketone hydrochlorides from aryl bromomethyl ketones and sodium diformylamide was described.