99159-15-6Relevant academic research and scientific papers
Selective Cleavage of Inert Aryl C-N Bonds in N-Aryl Amides
Zhang, Zhiguo,Zheng, Dan,Wan, Yameng,Zhang, Guisheng,Bi, Jingjing,Liu, Qingfeng,Liu, Tongxin,Shi, Lei
, p. 1369 - 1376 (2018/02/09)
A highly selective, IBX-promoted reaction has been developed for the oxidative cleavage of inert C(aryl)-N bonds on secondary amides while leaving the C(carbonyl)-N bond unchanged. This metal-free reaction proceeds under mild conditions (HFIP/H2O, 25 °C), providing facile access to various useful primary amides, some of which would be otherwise unattainable using conventional aminolysis and hydrolysis approaches.
RAMFORD-STEVENS REACTION IN THE SERIES OF 1-ACYL-1-R-CYCLOPROPANES
Kuznetsova, T. S.,Kozhushkov, S. I.,Gromov, A. V.,Vatlina, L. P.,Kozlovskii, V. I.,Zefirov, N. S.
, p. 256 - 262 (2007/10/02)
Investigation of the relationships governing the carbene decomposition of the monotosylhydrazones of 1-R-1-acylcyclopropanes showed that ?-accepting substituents at the gem position to the carbonyl group increase the stability of the three-membered ring under the conditions of the Bamford-Stevens reaction.This leads to partial suppression of the cyclopropylmethyl-cyclobutene isomerization process and, as a result, to the formation of 1,1-gem-alkenylcyclopropanes and bicyclobutanes.
Preparation and Cleavage of Some Cyclopropane Derivatives
Podder, Ranjan Kumar,Sarkar, Ranjit Kumar,Ray, Suvas C.
, p. 530 - 536 (2007/10/02)
Alkylation of active methylene compounds with 1,2-dibromoethane using anhyd.K2CO3/DMF at room temperature gives cyclopropane derivatives which undergo selective transformation by simple methods.Cyclopropanes, obtained by the condensation of α-diazoacetophenones with olefins, are cleaved to trisubstituted olefins with Grignard reagent.Hydration of the products has also been studied.
