99182-73-7

Upstream product

• 50-00-0 formaldehyd 
• 1193-18-6 3-methylcyclohexen-2-one 
• 75-16-1 methylmagnesium bromide 
• 2979-19-3 3,3-dimethylcyclohexanone 
• 110-88-3 1,3,5-Trioxan 
• 61175-92-6 3,3-dimethyl-1-<(trimethylsilyl)oxy>cyclohex-1-ene 

Downstream Products

• 134312-41-7 3,3-dimethyl-2-methylenecyclohexanone 
• 472-19-5 (2,2-dimethyl-6-methylenecyclohexyl)methanol 
• 432-23-5 2,2-dimethyl-6-methylenecyclohexane-1-carbaldehyde 
• 674781-64-7 (2,2-dimethyl-6-methylenecyclohexyl)-2-methylprop-2-enyl methyl carbonate 
• 1332864-91-1 C₄₀H₅₀N₂O₅Si 
• 1332864-63-7 2-(((tert-butyl)diphenylsilyloxy)methyl)-3,3-dimethyl-1-vinylcyclohexanol 
• 1332864-92-2 (E)-(tert-butyl) 1-(2-(2-(((tert-butyl)diphenylsilyloxy)methyl)-3,3-dimethylcyclohexylidene)ethyl)hydrazinecarboxylate 
• 1332864-62-6 2-(((tert-butyldiphenylsilyl)oxy)methyl)-3,3-dimethylcyclohexan-1-one 

Relevant academic research and scientific papers

Total Synthesis and Assignment of the Absolute Configuration of (+)-Omphalic Acid

Omphalane diterpenoids usually contain a cyclohexane-fused bicyclo[3.2.1]octane scaffold embedded with two continuous quaternary carbon centers, which pose considerable challenges to synthetic chemists. Herein, we reported the first total synthesis of omphalic acid with high stereochemical control, featuring an intermolecular Diels-Alder cycloaddition, ring reorganization through Criegee oxidative cleavage and programmed aldol condensations, conformationally controlled hydrogenation, and Pd-catalyzed carboxylation. The absolute configuration of omphalic acid was defined for the first time via the asymmetric total synthesis facilitated by a derivatization resolution protocol.

Ultralight mesoporous magnetic frameworks by interfacial assembly of prussian blue nanocubes

A facile approach for the synthesis of ultralight iron oxide hierarchical structures with tailorable macro- and mesoporosity is reported. This method entails the growth of porous Prussian blue (PB) single crystals on the surface of a polyurethane sponge, followed by in situ thermal conversion of PB crystals into three-dimensional mesoporous iron oxide (3DMI) architectures. Compared to previously reported ultralight materials, the 3DMI architectures possess hierarchical macro- and mesoporous frameworks with multiple advantageous features, including high surface area (ca. 117 m2 g-1) and ultralow density (6-11 mg cm-3). Furthermore, they can be synthesized on a kilogram scale. More importantly, these 3DMI structures exhibit superparamagnetism and tunable hydrophilicity/hydrophobicity, thus allowing for efficient multiphase interfacial adsorption and fast multiphase catalysis.

Total Synthesis of (+)-Acanthodoral by the Use of a Pd-Catalyzed Metal-ene Reaction and a Nonreductive 5-exo-Acyl Radical Cyclization

(Equation presented) The first total synthesis of the antibiotic acanthodoral (1) has been achieved from 3-methyl-2-cyclohexen-1-one in 19 steps in 2.1% overall yield. The synthesis features the use of a Pd-ene reaction in the presence of CO to form the endocyclic alkene 8, a nonreductive acyl radical cyclization reaction, and a ring contraction reaction by the Wolff rearrangement. (+)-Acanthodoral has also been synthesized starting from (+)-S-2,2-dimethyl-6-methylenecyclohexanecarboxylic acid.