99199-77-6

Upstream product

• 108-95-2 phenol 
• 90-02-8 salicylaldehyde 
• 1433064-21-1 C₁₃H₁₈O₄ 
• 1260168-27-1 2-(2-methoxyethenyl)phenol 
• 24698-77-9 ethyl Chroman-2-carboxylate 
• 74-88-4 methyl iodide 

Relevant academic research and scientific papers

Asymmetric induction via short-lived chiral enolates with a chiral C-O axis

A novel method has been developed for the asymmetric cyclization of alkyl aryl ethers. The reactions were assumed to proceed via short-lived chiral enolate intermediates with a chiral C-O axis to give cyclic ethers with tetrasubstituted carbon in up to 99% ee. The half-life of racemization of the chiral enolate intermediate was roughly estimated to be ～1 s at -78 C.

A highly efficient enantioselective synthesis of 2-methyl chromans via four sequential palladium-catalyzed reactions

An enantioselective synthesis of substituted 2-methyl chromans was accomplished in four steps using four sequential Pd-catalyzed reactions. A study of the key palladium-catalyzed regioselective aryl ether ring formation of two different substrates was also carried out to better understand the factors which affect the selectivity of the reaction.