99214-52-5

Basic information

• Product Name: 4,7-DIAZA-SPIRO[2.5]OCTANE
• Synonyms: 4,7-DIAZA-SPIRO[2.5]OCTANE;4,7-Diaza-spiro[2.5]octane 2HCl;4,7-Diazaspiro[2.5]octane hydrochloride
• CAS NO: 99214-52-5
• Molecular Formula: C6H12N2
• Molecular Weight: 112.17
• EINECS: 604-604-1
• Mol File: 99214-52-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 195℃
• Flash Point: 92℃
• Appearance: /
• Density: 1.05
• Vapor Pressure: 0.429mmHg at 25°C
• Refractive Index: 1.534
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4,7-DIAZA-SPIRO[2.5]OCTANE(CAS DataBase Reference)
• NIST Chemistry Reference: 4,7-DIAZA-SPIRO[2.5]OCTANE(99214-52-5)
• EPA Substance Registry System: 4,7-DIAZA-SPIRO[2.5]OCTANE(99214-52-5)

Safety Data

• Hazardous Substances Data: 99214-52-5(Hazardous Substances Data)

Usage

General Description

4,7-Diaza-spiro[2.5]octane is a chemical compound with the molecular formula C6H12N2. It is a bicyclic organic compound that contains a nitrogen atom in the spiro center. 4,7-DIAZA-SPIRO[2.5]OCTANE has a unique structure and is commonly used as a ligand in coordination chemistry, particularly in metal catalysis and organic synthesis. It also finds applications in pharmaceuticals and agrochemicals as a building block for various drugs and pesticides. 4,7-Diaza-spiro[2.5]octane is a versatile and important chemical compound with a wide range of applications in various fields of chemistry and industry.

InChI:InChI=1/C6H12N2/c1-2-6(1)5-7-3-4-8-6/h7-8H,1-5H2

Upstream product

• 129306-17-8 4,7-diazaspiro[2.5]octane-5,8-dione 
• 1199792-92-1 4-(trifluoroacetyl)-4,7-diazaspiro[2.5]octane hydrochloride 
• 1222106-43-5 7-benzyl-4,7-diazaspiro[2.5]octane-5,8-dione 
• 1222106-45-7 7-benzyl-4,7-diazaspiro[2.5]octane 

Downstream Products

• 886766-28-5 4,7-diazaspiro[2.5]octane-7-carboxylic acid tert-butyl ester 

Relevant articles and documents

A 4, 7 - diaza spiro [2.5] octane -7 - formic acid tert-butyl synthetic method

The invention belongs to the technical field of chemical synthesis of N-heterocycle-containing drug intermediates, and particularly relates to a synthesis method of tert-butyl 4,7-diazaspiro[2.5]octyl-7-formate. By using diethyl malonate as a raw material, cyclization reaction, Hofmann reaction, hydrolysis reaction, acylation reaction for recyclization, reduction reaction and the like are performed to conveniently synthesize the target compound product. The method has the advantages of simple synthesis technique, cheap and accessible raw materials, mild reaction conditions, high controllability, low cost and high yield, and is convenient to operate.

MORPHOLINOPURINE DERIVATIVES

There is provided a novel compound that inhibits phosphatidylinositol 3-kinase (PI3K) and/or the mammalian target of rapamycin (mTOR) and exhibits anti-tumor activity. The present invention provides a compound represented by the following formula (1) having various substituents that inhibits PI3K and/or mTOR and exhibits anti-tumor activity: wherein R1, R2, R3, R4, Ra, Rb, Rc, and X each have the same meaning as defined in the specification.