99221-09-7

Upstream product

• 1249-75-8 methyl lithocholate 
• 434-13-9 Lithocholic acid 
• 220134-48-5 C₃₆H₄₅N₃O₆ 
• 220134-41-8 tert-butyl(((3R,5R,8R,9S,10S,13R,14S,17R)-17-((R)-5-iodopentan-2-yl)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-3-yl)oxy)dimethylsilane 
• 220134-42-9 3α-(tert-butyldimethylsilyloxy)-20(R)-(3-cyanopropyl)pregnane 
• 220134-43-0 3α-hydroxy-20(R)-(3-ethoxycarbonylpropyl)pregnane 
• 220134-46-3 3β-acetyloxy-20(R)-(3-methoxycarbonylpropyl)pregna-1,5-diene 
• 220134-47-4 (R)-5-((3R,9S,10R,13R,14R,17R)-3-Acetoxy-10,13-dimethyl-4,9,10,11,12,13,14,15,16,17-decahydro-3H-cyclopenta[a]phenanthren-17-yl)-hexanoic acid methyl ester 
• 220134-44-1 20(R)-(3-ethoxycarbonylpropyl)pregna-1,4-dien-3-one 
• 220134-45-2 20(R)-(3-methoxycarbonylpropyl)pregna-1,5-dien-3-one 
• 129779-44-8 3β-hydroxy-20(R)-(3-methoxycarbonylpropyl)pregna-1,5-diene 
• 84529-93-1 (R)-4-((3R,5R,8R,9S,10S,13R,14S,17R)-3-((tert-butyldimethylsilyl)oxy)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentan-1-ol 
• 91788-51-1 methyl (3α,5β)-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]cholan-24-oate 

Downstream Products

• 99221-10-0 C₄₀H₅₇N₃O₅Si 
• 99221-11-1 C₄₀H₅₇N₃O₆Si 

Relevant academic research and scientific papers

Syntheses and preventive effects of analogues related to 1α,25-dihydroxy-2β-(3-hydroxypropoxy)vitamin D3 (ED-71) on bone mineral loss in ovariectomized rats

Analogues related to 1α,25-dihydroxy-2β-(3-hydroxypropoxy)vitamin D3 (ED-71) (2), 26,27-dimethyl ED-71 (3) and 26,27-diethyl ED-71 (4), were synthesized from lithocholic acid (5). In the study of the preventive effects of these analogues and ED-71 (2) on bone mineral loss in ovariectomized rats, 26,27-dimethyl ED-71 (3) showed the most potent activity. Copyright (C) 1998 Elsevier Science Ltd.