220134-48-5Relevant articles and documents
Syntheses and preventive effects of analogues related to 1α,25-dihydroxy-2β-(3-hydroxypropoxy)vitamin D3 (ED-71) on bone mineral loss in ovariectomized rats
Ono, Yoshiyuki,Kawase, Akira,Watanabe, Hiroyoshi,Shiraishi, Ayako,Takeda, Satoshi,Higuchi, Yoshinobu,Sato, Katsuhiko,Yamauchi, Tsuyoshi,Mikami, Tetsuhiro,Kato, Masahiro,Tsugawa, Naoko,Okano, Toshio,Kubodera, Noboru
, p. 2517 - 2523 (1998)
Analogues related to 1α,25-dihydroxy-2β-(3-hydroxypropoxy)vitamin D3 (ED-71) (2), 26,27-dimethyl ED-71 (3) and 26,27-diethyl ED-71 (4), were synthesized from lithocholic acid (5). In the study of the preventive effects of these analogues and ED-71 (2) on bone mineral loss in ovariectomized rats, 26,27-dimethyl ED-71 (3) showed the most potent activity. Copyright (C) 1998 Elsevier Science Ltd.