99237-42-0Relevant academic research and scientific papers
Self-immolative prodrugs: Candidates for antibody-directed enzyme prodrug therapy in conjunction with a nitroreductase enzyme
Mauger,Burke,Somani,Friedlos,Knox
, p. 3452 - 3458 (1994)
The synthesis and properties of some prodrug candidates for antibody- directed enzyme prodrug therapy (ADEPT) are described. These compounds have been designed to generate the corresponding active drug upon interaction with a bacterial nitroreductase that
Synthesis of photo-responsive acridine-modified DNA and its application to site-selective RNA scission
Tanaka, Keita,Yamamoto, Yoji,Kuzuya, Akinori,Komiyama, Makoto
, p. 1175 - 1185 (2008/12/23)
Photo-responsive phosphoramidite monomers, which bear an azobenzene between acridine and the phosphoramidite unit, were synthesized, and incorporated into oligonucleotides. Upon UV irradiation, the azobenzene in the modified DNA efficiently isomerized from the trans isomer into the cis isomer. Although the Tm values of their duplexes with complementary DNA were not much changed by the isomerization, site-selective RNA scission was significantly accelerated by the UV irradiation when Mn(II) ion was used as the catalyst for RNA scission. Copyright Taylor & Francis Group, LLC.
Leaving group effects in reductively triggered fragmentation of 4-nitrobenzyl carbamatesf
Sykes, Bridget M.,Hay, Michael P.,Bohinc-Herceg, Dubravka,Helsby, Nuala A.,O'Connor, Charmian J.,Denny, William A.
, p. 1601 - 1608 (2007/10/03)
The rates and extent of release of a series of substituted anilines from 4-nitrobenzyl carbamates, following nitro group reduction by radiolytic, enzymic and chemical methods, are reported. The yield of released anilines decreased over the pH range 4-7, b
Kinetics and Mechanism of Polarographic Reduction of Aromatic Nitro Compounds in Aqueous Alcoholic Medium
Ratan, Ram,Rani, Rama,Singh, Mukhtar
, p. 664 - 670 (2007/10/02)
Polarographic reduction of nitrobenzene, ortho-, meta- and para- chloronitrobenzenes, nitrotoluenes, nitrophenols and nitrobenzaldehydes has been studied in 25percent (v/v) aqueous ethanolic solutions, using Britton-Robinson (BR) buffer of varying pH values.KCl (0.1 M) has been used as the supporting electrolyte and Triton X-100 (0.001percent) as the maxima suppressor.The potential-dependent rate constant, kf,h has been calculated by Koutecky's method at different pH values and the values of kinetic parameters (αna and kf,h) have been calculated from logkf,h versus Ed.e. plots which are linear thereby suggesting that only a single rate-determining step is involved in the electrode process of each depolarizer.Based on the values of kinetic parameter, αna and the variation of E1/2 with pH, the stoichiometry of the rate-determining step has been established.This has led to the postulation of a tentative mechanism for the polarographic reduction of each depolarizer.Besides, the effect of the nature and position of various substituents, viz.Cl, CH3, OH and CHO on the kinetics of the polarographic reduction of NO2 group has been investigated.
