Self-immolative prodrugs: Candidates for antibody-directed enzyme prodrug therapy in conjunction with a nitroreductase enzyme

DOI: 10.1021/jm00047a002

Source and publish data:

Journal of Medicinal Chemistry p. 3452 - 3458 (1994)

Update date:2022-08-10

Topics:

Authors:

Mauger Mauger

Burke Burke

Somani Somani

Friedlos

Knox Knox

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Article abstract of DOI:10.1021/jm00047a002

The synthesis and properties of some prodrug candidates for antibody- directed enzyme prodrug therapy (ADEPT) are described. These compounds have been designed to generate the corresponding active drug upon interaction with a bacterial nitroreductase that

Full text of DOI:10.1021/jm00047a002

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