13391-27-0Relevant academic research and scientific papers
Synthesis of benzofurans via Pd2+-catalyzed oxidative cyclization of 2-allylphenols
Roshchin, Alexander I.,Kel'chevski, Sergey M.,Bumagin, Nikolai A.
, p. 163 - 167 (1998)
Substituted 2-methylbenzofurans were obtained from 2-allylphenols via Pd2+-catalyzed oxidative cyclization using Cu(OAc)2-LiCl as a reoxidant and wet DMF as a solvent.
Preparation of substituted hydroquinones and benzofurans from 1,4-quinone monoketals
Salom-Roig, Xavier J.,Renaud, Philippe
, p. 3419 - 3424 (2006)
An easy procedure for the preparation of 2-substituted hydroquinones, by addition of organolithium or organomagnesium compounds to 1,4-quinone monoketals followed by acid-catalyzed dienone-phenol type rearrangement, is described. Transformation of the pro
TRICYCLIC FURAN-SUBSTITUTED PIPERIDINEDIONE COMPOUND
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Paragraph 0132; 0135, (2021/07/17)
Disclosed are a series of tricyclic furan-substituted piperidinedione compounds and an application thereof in preparing a drug for treating a disease related to CRBN protein. In particular, disclosed is a derivative compound represented by formula (I) or a pharmaceutically acceptable salt thereof.
TRICYCLIC SUBSTITUTED PIPERIDINE DIONE COMPOUND
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Paragraph 0107; 0110, (2021/07/17)
Disclosed is a series of tricyclic substituted piperidine dione compounds, and applications thereof in the preparation of medicines for treating diseases related to CRBN protein; specifically disclosed are the derivative compound represented by formula (I) or a pharmaceutically acceptable salt thereof.
Enantio- and Diastereoselective, Complete Hydrogenation of Benzofurans by Cascade Catalysis
Gallagher, Timothy,Glorius, Frank,Hu, Tianjiao,Moock, Daniel,Wagener, Tobias
supporting information, p. 13677 - 13681 (2021/05/10)
We report an enantio- and diastereoselective, complete hydrogenation of multiply substituted benzofurans in a one-pot cascade catalysis. The developed protocol facilitates the controlled installation of up to six new defined stereocenters and produces architecturally complex octahydrobenzofurans, prevalent in many bioactive molecules. A unique match of a chiral homogeneous ruthenium-N-heterocyclic carbene complex and an in situ activated rhodium catalyst from a complex precursor act in sequence to enable the presented process.
Synthesis of Benzo[ b]furans by Intramolecular C-O Bond Formation Using Iron and Copper Catalysis
Henry, Martyn C.,Sutherland, Andrew
, p. 2766 - 2770 (2020/03/30)
One-pot processes for the synthesis of benzo[b]furans from 1-aryl- or 1-alkylketones using nonprecious transition metal catalysts have been developed. Regioselective iron(III)-catalyzed halogenation of the aryl ring, followed by iron- or copper-catalyzed O-arylation allowed the synthesis of various structural analogues, including the benzo[b]furan-derived natural products corsifuran C, moracin F, and caleprunin B.
Pd-catalyzed intramolecular Heck reaction for the synthesis of 2-methylbenzofurans
Zhou,Shi, Yuxing,Zhu, Xueyan,Zhang, Peng
, p. 2005 - 2008 (2019/07/03)
A new strategy for the synthesis of 2-Methylbenzofurans via the intramolecular Heck reaction has been developed. This efficient palladium-catalyzed system showed good catalytic activity. Various substituted 2-methylbenzofurans could be afforded in good to excellent yields.
Synthesis of Functionalized Benzo[b]furans via Oxidative Cyclization of o-Cinnamyl Phenols
Rehan, Mohammad,Nallagonda, Rajender,Das, Braja Gopal,Meena, Tannu,Ghorai, Prasanta
, p. 3411 - 3424 (2017/04/13)
Disclosed herein is an efficient synthetic route for the synthesis of functionalized 2-benzyl benzo[b]furans via a regioselective 5-exo-trig intramolecular oxidative cyclization of ortho-cinnamyl phenols using [PdCl2(CH3CN)2] as catalyst and benzoquinone as an oxidant. Further, a sequential ortho-cinnamylation of phenols using cinnamyl alcohols catalyzed by Re2O7, followed by an oxidative cyclization using the above Pd catalyst, is performed. The reaction showed broad substrate scope with good to excellent yields.
Natural tanshinone-like heterocyclic-fused ortho-quinones from regioselective Diels-Alder reaction: Synthesis and cytotoxicity evaluation
Shen, Yu-Dong,Tian, Yuan-Xin,Bu, Xian-Zhang,Gu, Lian-Quan
scheme or table, p. 3915 - 3921 (2009/12/04)
A series of new natural tanshinone-like oxoheterocyclic-fused ortho-quinone derivatives were synthesized from readily available benzofuranol and N-substituted dienes via IBX oxidation-cycloaddition-aromatization procedure. The regiospecific Diels-Alder cycloaddition reactions of N-dienes were achieved efficiently with a variety of dienophiles. It is found that the amide moiety in the molecular could be preserved or eliminated by control of the aromatization conditions. Selected oxoheterocyclic-fused ortho-quinones as well as several thioheterocyclic-fused ortho-quinones we obtained before were evaluated for their cytotoxicities on different cancer cell lines and the Structure-Activity Relationship (SAR) was discussed.
Simple and efficient access to 3-ethoxycarbonylpyrroles, naphthofurans
Pancote, Camila G.,De Carvalho, Bruno S.,Luchez, Cibele V.,Fernandes, Joao P.S.,Politi, Mario J.,Brandt, Carlos A.
experimental part, p. 3963 - 3966 (2010/03/26)
An efficient method was developed for the synthesis of pyrrole and furan derivatives from enamines, phenols, and naphthols. The key steps involve iodocyclization and alumina-induced dehydroiodination reactions. Georg Thieme Verlag Stuttgart.
