99254-90-7

Usage

Uses

Used in Pharmaceutical Industry:
Benzene, 1,3-dichloro-5-ethynylis used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows for the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical industry, Benzene, 1,3-dichloro-5-ethynylis utilized as a precursor for the production of various agrochemicals, such as pesticides and herbicides. Its chemical properties make it suitable for the development of effective and targeted agricultural products.
Used in Dye Industry:
Benzene, 1,3-dichloro-5-ethynylis also used in the dye industry for the production of various dyes and pigments. Its chemical structure contributes to the creation of vibrant and stable colorants for a wide range of applications.
Used in Chemical and Solvent Production:
As an intermediate, Benzene, 1,3-dichloro-5-ethynylplays a crucial role in the production of various chemicals and solvents. Its versatility in chemical reactions enables the synthesis of a broad range of products for different industries.
Safety Precautions:

Upstream product

• 351865-83-3 2-(3,5-dichlorophenyl)ethynyl-trimethylsilane 
• 19752-55-7 1-bromo-3,5-dichlorobenzene 
• 3032-81-3 3,5-dichloroiodobenzene 
• 93427-13-5 3,5-Dichloro-β-phenethyl alcohol 

Downstream Products

• 99254-91-8 Copper I (3,5-Dichlorophenyl)acetylide 
• 1040264-89-8 C₃₄H₄₃Cl₂N₇O₇S 
• 1352764-63-6 C₁₅H₈Cl₂O 
• 1391056-92-0 C₁₈H₁₅Cl₂NO₃ 
• 1391056-94-2 C₁₆H₉Cl₂NO₃ 
• 1391056-65-7 C₁₇H₁₃Cl₂NO₃ 

Relevant academic research and scientific papers

SO2F2-Mediated Oxidative Dehydrogenation and Dehydration of Alcohols to Alkynes

Direct synthesis of alkynes from inexpensive, abundant alcohols was achieved in high yields (greater than 40 examples, up to 95% yield) through a SO2F2-promoted dehydration and dehydrogenation process. This straightforward transformation of sp3-sp3 (C-C) bonds to sp-sp (C=C) bonds requires only inexpensive and readily available reagents (no transition metals) under mild conditions. The crude alkynes are sufficiently free of impurities to permit direct use in further transformations, as illustrated by regioselective Huisgen alkyne-azide cycloaddition reactions with PhN3 to give 1,4-substituted 1,2,3-traiazoles (16 examples, up to 92% yield) and Sonogashira couplings (10 examples, up to 77% yield).

SUBSTITUTED PYRAZOLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE

The present invention relates to substituted pyrazoles, compositions containing such compounds and methods of treatment. The compounds are glucagon receptor antagonists and thus are useful for treating, preventing or delaying the onset of type 2 diabetes

Novel 3-phenylprop-2-ynylamines as inhibitors of mammalian squalene epoxidase.

The synthesis of a novel series of 3-phenylprop-2-ynylamines as selective mammalian squalene epoxidase inhibitors is described. Structure activity relationship studies led to the discovery of compound 19, 1-[3-(3,5-dichlorophenyl)-prop-2-ynyl]-3- methylpiperidine hydrochloride with an IC50 of 2.8 +/- 0.6 microM against rat liver squalene epoxidase. Against 23 strains of fungal squalene epoxidase compound 19 was found to be inactive.

Substituted indoles and their use as integrin antagonists

The present invention relates to novel substituted indole compounds that are antagonists of alpha V (αv) integrins, for example αvβ3 and αvβ5 integrins, their pharmaceutically acceptable salts, and pharmaceutical compositions thereof. The compounds may be used in the treatment of pathological conditions mediated by αvβ3 and αvβ5 integrins, including such conditions as tumor growth, metastasis, restenosis, osteoporosis, inflammation, macular degeneration, diabetic retinopathy, and rheumatoid arthritis. The compounds have the general formula: where R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, D, X, W, a, m, n, i, j, k and v are defined herein.

Methods for the treatment of hypertension

Acetylene compounds of the formula (I): STR1 wherein Y, R1, R2, R3, and R4 are as described herein, m is 0-3, n is 0-2 and Ar is phenyl or an aromatic heterocycle are disclosed. The compounds possess antihyperte

Acetylenic phenoxypropanol derivatives and pharmaceutical compositions for the treatment of hypertension

Phenoxypropanol derivatives having a 2-acetylenic moiety on the phenyl group thereof of the following formula (I): STR1 and their use as anti-hypertensives, e.g. in man. Also part of the invention are pharmaceutical compositions and intermediates used in

Aralykyl (arylethynyl)aralkyl amines and their use as vasodilators and antihypertensives

Acetylenes of the formula (I): STR1 wherein Y, m, R1, R2 q, Alk, R3, n and R4 are as defined herein and Ar1 and Ar2 are aromatic, including the salts and ammonium derivatives of formula (I), in treating angina, hypertension and cardiac arrhythmias. Pharmaceutical compositions, methods of use and synthesis and novel intermediates are also part of the invention.