99366-04-8

Upstream product

• 100-01-6 4-nitro-aniline 
• 135-19-3 β-naphthol 
• 52010-83-0 (E)-1-((4-nitrophenyl)diazenyl)piperidine 
• 18081-08-8 2-naphthyl trimethylsilyl ether 

Downstream Products

• 620-89-3 4-methyl-N-(4-nitrophenyl)aniline 
• 501-60-0 1,2-di(p-tolyl)diazene 
• 93449-57-1 1,2-Naphthochinon-1-<(4-nitrophenyl)hydrazon> 
• 99366-12-8 1-(4-Nitro-phenylazo)-naphthalen-2-ol 

Relevant academic research and scientific papers

A green alternative to synthetize azo compounds

Different nitrates were used as sources of nitrosonium ion to obtain diazonium salts. Diverse azo compounds were synthetized in acetonitrile giving very good yields and free of by-products in comparison with traditional synthesis. Among the tested species, the best combination for para red synthesis was nitric acid and gaseous hydrogen chloride.

Diaryl azo derivatives as anti-diabetic and antimicrobial agents: synthesis, in vitro, kinetic and docking studies

In the present study, a series of azo derivatives (TR-1 to TR-9) have been synthesised via the diazo-coupling approach between substituted aromatic amines with phenol or naphthol derivatives. The compounds were evaluated for their therapeutic applications against alpha-glucosidase (anti-diabetic) and pathogenic bacterial strains E. coli (gram-negative), S. aureus (gram-positive), S. aureus (gram-positive) drug-resistant strain, P. aeruginosa (gram-negative), P. aeruginosa (gram-negative) drug-resistant strain and P. vulgaris (gram-negative). The IC50 (μg/mL) of TR-1 was found to be most effective (15.70 ± 1.3 μg/mL) compared to the reference drug acarbose (21.59 ± 1.5 μg/mL), hence, it was further selected for the kinetic studies in order to illustrate the mechanism of inhibition. The enzyme inhibitory kinetics and mode of binding for the most active inhibitor (TR-1) was performed which showed that the compound is a non-competitive inhibitor and effectively inhibits the target enzyme by binding to its binuclear active site reversibly.

Exploring flow procedures for diazonium formation

The synthesis of diazonium salts is historically an important transformation extensively utilized in dye manufacture. However the highly reactive nature of the diazonium functionality has additionally led to the development of many new reactions including

Azo compounds reducing formation and toxicity of amyloid beta aggregation intermediates

The present invention relates to compounds suitable as modulators of protein misfolding and/or protein aggregation. The compounds are particularly suitable as inhibitors of amyloid aggregate formation and/or modulators of amyloid surface properties, and/or as activators of degradation or reduction of amyloid aggregates.

The sequel to a carbocyclic nucleoside synthesis: A divergent access to both arenediazonium ions and aryl triflates

Depending on the amount of acid used, treating aryl-dialkyl triazenes of general structure 3 with triflic acid resulted in the formation of either the corresponding arenediazonium triflates 4 or aryl triflates 8 apparently by two different pathways, the latter conversion being favoured at high acid concentration.