99395-04-7

Basic information

• Product Name: 1-O-acetyl-2,3,5-tri-O-benzoyl-D-xylofuranose
• Synonyms: 1-O-acetyl-2,3,5-tri-O-benzoyl-D-xylofuranose
• CAS NO: 99395-04-7
• Molecular Weight: 504.493
• Mol File: 99395-04-7.mol
• Article Data: 23

Chemical Properties

• CAS DataBase Reference: 1-O-acetyl-2,3,5-tri-O-benzoyl-D-xylofuranose(CAS DataBase Reference)
• NIST Chemistry Reference: 1-O-acetyl-2,3,5-tri-O-benzoyl-D-xylofuranose(99395-04-7)
• EPA Substance Registry System: 1-O-acetyl-2,3,5-tri-O-benzoyl-D-xylofuranose(99395-04-7)

Safety Data

• Hazardous Substances Data: 99395-04-7(Hazardous Substances Data)

Upstream product

• 171866-28-7 1-O-methyl-2,3,5-tri-O-benzoyl-L-ribofuranose 
• 108-24-7 acetic anhydride 
• 87-72-9 L-xylopyranose 
• 24259-59-4 L-ribose 
• 98-88-4 benzoyl chloride 
• 1173695-22-1 1-O-acetyl-2,3,5-tri-O-benzoyl-α-L-ribofuranose 
• 87-72-9 L-ribose 
• 7296-55-1 L-arabinose 
• 65247-32-7 benzyl 3,4-O-(1-methylethylidene)-β-L-erythro-pent-2-ulosylpyranoside 
• 26685-74-5 1-O-benzyl-3,4-O-isopropylidene-β-L-ribopyranose 
• 192133-10-1 Acetic acid (1R,2S)-2,3-diacetoxy-1-((R)-1-acetoxy-2-hydroxy-ethyl)-propyl ester 
• 192133-11-2 L-ribose 2,3,4,5-tetraacetate 
• 95622-16-5 5-O-trityl-D-ribitol 
• 55726-00-6 (3R,4S,5R)-5-((trityloxy)methyl)tetrahydrofuran-2,3,4-triol 

Downstream Products

• 90301-37-4 (2,3,5-tri-O-benzoyl-β-D-xylofuranosyl)cyanide 
• 664994-58-5 3-(2-methoxyphenoxy)-1-O-(2,3,5-tri-O-benzoyl-β-D-xylofuranosyl)propane-1,2-diol 
• 206269-23-0 2,3,5-tri-O-benzoyl-β-L-ribofuranosyl azide 
• 206269-35-4 dimethyl 2-(2',3',4'-tri-O-benzoyl-β-L-ribofuranosyl)-1,2,3-triazole-4,5-dicarboxylate 
• 206269-43-4 1-(2',3',5'-tri-O-benzoyl-β-L-ribofuranosyl)-6-methyluracil 
• 206269-45-6 1-(2,3,5-tri-O-benzoyl-β-L-ribofuranosyl)-5-azacytosine 
• 206269-47-8 1-(2',3',5'-tri-O-benzoyl-β-L-ribofuranosyl)-6-azauracil 
• 58-61-7 adenosine 
• 173009-65-9 1,2-di-O-acetyl-3,5-di-O-benzoyl-α-L-ribofuranose 
• 1173695-22-1 1-O-acetyl-2,3,5-tri-O-benzoyl-α-L-ribofuranose 
• 173009-66-0 1,2-di-O-acetyl-3,5-di-O-benzoyl-β-L-ribofuranose 
• 1343405-34-4 C₃₂H₂₂ClN₅O₇ 
• 1350887-25-0 4-amino-6-(3-bromophenyl)-5-cyano-7-(2,3,5-tri-O-benzoyl-β-L-xylofuranosyl)pyrrolo[2,3-d]pyrimidine 
• 1350887-26-1 4-amino-6-(1H-pyrrol-2-yl)-5-cyano-7-(2,3,5-tri-O-benzoyl-β-L-xylofuranosyl)pyrrolo[2,3-d]pyrimidine 

Relevant articles and documents

L-nucleoside compounds and application thereof

The invention discloses L-nucleoside compounds having the structure characteristic represented by the formula (I) or pharmaceutically acceptable salts thereof, and belongs to the technical field of pharmaceutical chemistry. The compounds can inhibit the activity of RNA viral polymerase, so the compounds can be used as potential drugs for prevention and treatment of infection of RNA viruses such as HCV, influenza virus, HRV (rhinovirus), RSV, Ebola virus, dengue virus, intestinal virus and the like.

Synthesis of 6-(het) ary Xylocydine analogues and evaluating their inhibitory activities of CDK1 and CDK2 in vitro

A series of purine nucleoside analogues bearing an aryl and hetaryl group in position 6 were prepared and their biological activities were assessed by in vitro CDK1/Cyclin B1 and CDK2/Cyclin A2 kinase assay. From the synthesized chemicals, three Xylocydine derivatives 3h, 3i, and 3j exhibited specific inhibitory activities on CDK2/Cyclin A2 with IC50 values of 4.6, 4.8, and 55 μM, respectively. Those three compounds all induced G1/S phase arrest in Human epithelial carcinoma cell line (HeLa), and the results suggested they may inhibit CDK2 activity in vitro. Furthermore, molecular modeling study, their docking into Cyclin Dependant Kinase 2 (CDK2) active site showed high docking scores. Taken together, these data suggest that, those three compounds are good inhibitors of CDK2 for studying this kinase signal transduction pathway in cell system.

METHOD FOR PRODUCTION OF FURANOSE DERIVATIVE

An object of the present invention is to provide a industrially appropriate method for producing the β-anomers of ribofuranose derivatives in a highly selective manner at a high yield. The present invention provides a method for producing ribofuranose derivatives wherein β-anomers is precipitated from among the generated furanose derivatives by controlling the amount of a reaction reagent used and/or using a poor solvent in the acetolysis reactions of 2,3,5-tri-O-acyl-1-O-alkyl-ribofuranose and 2,3-di-O-acyl-1-O-alkyl-5-deoxy-ribofuranose.