99407-64-4Relevant academic research and scientific papers
A catalytic enantioselective conjugate addition of cyanide to enones
Tanaka, Yuta,Kanai, Motomu,Shibasaki, Masakatsu
, p. 6072 - 6073 (2008/12/20)
The first synthetically useful catalytic enantioselective conjugate addition of cyanide to enones is described. The optimized conditions involved a Gd catalyst (5 or 10 mol %) derived from ligands 3 or 4 and a 1:1 ratio of TBSCN and 2,6-dimethylphenol. Th
Enzymatic in vitro Reduction of Ketones. Part 13. Horse Liver Alcohol Dehydrogenase (HLAD) as a Tool for the Synthesis of Enantiomerically Pure Alkyl 3-oxo- and 3-hydroxycyclohexanecarboxylates.
Willaert, J. J.,Lemiere, G. L.,Dommisse, R. A.,Lepoivre, J. A.,Alderweireldt, F. C.
, p. 2401 - 2423 (2007/10/02)
Enantiomerically pure alkyl 3-oxocyclohexanecarboxylates and the corresponding alcohols have been prepared using HLAD as a suitable catalyst.Kinetic and thermodynamic parameters for the enzymatic reductions are given.The enantiomeric purity and the absolute configuration of the reaction products are determined.The alcohol moiety (methyl, isopropyl or pentyl) of the ester group influences both the steric course and the kinetics of the reduction.Side reactions of the substrate with the reaction medium can be avoided by an appropriate choice of the reaction conditions.
