149055-86-7

Upstream product

• 67-56-1 methanol 
• 99799-10-7 3-methoxy-1-cyclohexanecarboxylic acid 
• 124-41-4 sodium methylate 
• 4350-83-8 6-oxabicyclo[3.2.1]octan-7-one 
• 4350-83-8 6-oxa-bicyclo[3.2.1]octan-7-one 
• 99407-64-4 (+/-)-methyl 3,3-dimethoxycyclohexanecarboxylate 
• 37722-82-0 methyl 3-hydroxycyclohexanecarboxylate 
• 17983-30-1 (RS)-3-oxocyclohexanecarbonitrile 
• 21531-47-5 3-oxo-cyclohexanecarboxylic acid methyl ester 
• 606488-94-2 3-hydroxycyclohexane-1-carboxylic acid 
• 186581-53-3 diazomethane 
• 21531-44-2 (+/-)-cis-3-hydroxycyclohexanecarboxylic acid 
• 19438-10-9 methyl 3-hydroxybenzoate 
• 21531-44-2 (+/-)-trans-3-hydroxycyclohexanecarboxylic acid 

Downstream Products

• 21531-47-5 3-oxo-cyclohexanecarboxylic acid methyl ester 
• 1067908-05-7 6-methyl-1-{1-[cis-3-(propyloxy)cyclohexyl]-4-piperidinyl}-1,3-dihydro-2H-benzimidazol-2-one hydrochloride 
• 1067908-07-9 6-methyl-1-{1-[cis-3-(propyloxy)cyclohexyl]-4-piperidinyl}-1,3-dihydro-2H-benzimidazol-2-one hydrochloride 

Relevant academic research and scientific papers

1- (1-CYCLOHEXYL-4-PIPERIDINYL) -1, 3-DIHYDRO-2H-BENZIMIDAZOL-2-ONE DERIVATIVES WHICH HAVE ACTIVITY ON THE M1 RECEPTOR AND THEIR USE IN MEDICINE

Compounds of formula (I) or a salt thereof are provided, wherein R4, R5, R6, Q and R are as defined in the description. Uses of the compounds as medicaments and in the manufacture of medicaments for treating psychotic disorders and cognitive impairments are disclosed. The invention further discloses pharmaceutical compositions comprising the compounds.

METHOD FOR THE PREPARATION OF ENANTIOMER FORMS OF CIS-CONFIGURED 3-HYDROXYCYCLOHEXANE CARBOXYLIC ACID DERIVATIVES USING HYDROLASES

The present invention relates to a process for preparing chiral non-racemic cis-configured cyclohexanols or cyclohexanol derivatives of the formula (I) Cis-configured hydroxyl-cyclohexane carboxylic acid derivatives of formula (I) are central building blo

Enzymatic in vitro Reduction of Ketones. Part 13. Horse Liver Alcohol Dehydrogenase (HLAD) as a Tool for the Synthesis of Enantiomerically Pure Alkyl 3-oxo- and 3-hydroxycyclohexanecarboxylates.

Enantiomerically pure alkyl 3-oxocyclohexanecarboxylates and the corresponding alcohols have been prepared using HLAD as a suitable catalyst.Kinetic and thermodynamic parameters for the enzymatic reductions are given.The enantiomeric purity and the absolute configuration of the reaction products are determined.The alcohol moiety (methyl, isopropyl or pentyl) of the ester group influences both the steric course and the kinetics of the reduction.Side reactions of the substrate with the reaction medium can be avoided by an appropriate choice of the reaction conditions.