99458-26-1Relevant articles and documents
An Efficient, Enantioselective Synthesis of the Taxol Side Chain
Denis, Jean-Noel,Greene, Andrew E.,Serra, A. Aarao,Luche, Marie-Jacqueline
, p. 46 - 50 (2007/10/02)
An asymmetric epoxidation (70-80percent ee) and a highly regioselective epoxide cleavage have been used as the key reactions in the synthesis of the taxol side chain methyl ester (2; 95percent ee, 23percent overall yield from phenylacetylene.Transesterifications of 2 (in four steps) have been effected and are exemplified with (-)-isopinocampheol (8), 1,2;3,4-di-O-isopropylidene-D-galactopyranose (9), and methyl gibberellate (10).