99483-17-7Relevant articles and documents
Use of the 2-Pyridinesulfonyloxy Leaving Group for the Fast Copper-Catalyzed Coupling Reaction at Secondary Alkyl Carbons with Grignard Reagents
Shinohara, Riku,Morita, Masao,Ogawa, Narihito,Kobayashi, Yuichi
, p. 3247 - 3251 (2019/05/10)
Investigation of the copper-catalyzed coupling reaction of 2-pyridinesulfonates with Grignard reagents revealed that reactions with catalytic Cu(OTf)2 were completed in 40 min. The results differed from those of the previous CuI-catalyzed reactions of tosylates in the presence of additives (LiOMe and TMEDA) for 12-24 h. It was shown that the preferred coordination of the leaving group to the reagents accelerated the reaction. Successful reagents were MeMgCl and other RMgX. Complete inversion was established.
Elaboration of the ether cleaving ability and selectivity of the classical Pearlman's catalyst [Pd(OH)2/C]: Concise synthesis of a precursor for a myo-inositol pyrophosphate
Mart, Alson,Shashidhar, Mysore S.
, p. 9769 - 9776 (2013/01/13)
The cleavage of propargyl, allyl, benzyl, and PMB ethers by Pd(OH) 2/C can be tuned in that order, by varying the reaction conditions. Other moieties such as C-C double bonds, esters, trityl ether, p-bromo and p-nitrobenzyl ethers are stable to these reaction conditions. Cleavage of allyl ethers can be made catalytic by using 1:1 mixture of Pd(OH)2/C and Pd/C. The synthetic potential of the selective ether cleaving ability of Pd(OH)2/C, essentially under neutral conditions, has been demonstrated by an efficient synthesis of a precursor for the preparation of an inositol pyrophosphate derivative.
Reaction of Trifluoromethyl Ketones. V. Dehydration of Trifluoromethylated Homoallyl Alcohols: Synthesis of Trifluoromethylated Dienes
Nagai, Takabumi,Hama, Masayoshi,Yoshioka, Masahiko,Yuda, Mariko,Yoshida, Noriko,et al.
, p. 177 - 183 (2007/10/02)
1-(Trifluoromethyl)homoallyl alcohols, which were obtained by the ene reaction of trifuoromethyl ketones with olefins, were dehydrated with POCl3-pyridine or other acyl halide-organic base mixtures to trifluoromethylated dienes.Dehydration of the homoally
