99484-07-8

Basic information

• Product Name: N-((4-methylphenyl)methylene)-1-propanamine
• Synonyms: N-((4-methylphenyl)methylene)-1-propanamine
• CAS NO: 99484-07-8
• Molecular Weight: 161.247
• Mol File: 99484-07-8.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: N-((4-methylphenyl)methylene)-1-propanamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-((4-methylphenyl)methylene)-1-propanamine(99484-07-8)
• EPA Substance Registry System: N-((4-methylphenyl)methylene)-1-propanamine(99484-07-8)

Safety Data

• Hazardous Substances Data: 99484-07-8(Hazardous Substances Data)

Upstream product

• 107-10-8 propylamine 
• 39184-65-1 3-chloro-3-(4-methylphenyl)diaziridine 
• 104-87-0 4-methyl-benzaldehyde 
• 60859-72-5 ethyl 2-nitro-3-(p-tolyl)acrylate 
• 52287-56-6 (E)-1-methyl-4-(2-nitroprop-1-en-1-yl)benzene 

Downstream Products

• 4714-21-0 E-1-methyl-4-styryl-benzene 

Relevant articles and documents

Aza-Nazarov Cyclization Reactions via Anion Exchange Catalysis

A catalytic aza-Nazarov cyclization between 3,4-dihydroisoquinolines and α,β-unsaturated acyl chlorides has been developed to access α-methylene-γ-lactam products in good yields (up to 79%) as single diastereomers. The reactions proceed efficiently when AgOTf is used as an anion exchange catalyst with a 20 mol % loading at 80 °C. Computational studies were performed to investigate the reaction mechanism, and the findings support the role of the -TMS group in reducing the reaction barrier of the key cyclization step.

Methyl-triflate-mediated dearylmethylation of: N -(arylmethyl)carboxamides via the retro-Mannich reaction induced by electrophilic dearomatization/rearomatization in an aqueous medium at room temperature

We have developed a protocol for the dearylmethylation of N-(arylmethyl)carboxamides under metal-free conditions in an aqueous medium at room temperature. This protocol involves methyl triflate-mediated successive C-C and C-N bond cleavages (retro-Mannich reaction) induced by electrophilic dearomatization/rearomatization. The dearomatization/rearomatization strategy can be expected to inspire the development of novel transformations based on the C-C bond cleavage in an environmentally benign manner.

Simple Metal-Free Direct Reductive Amination Using Hydrosilatrane to Form Secondary and Tertiary Amines

This work describes the use of cheap, safe, and easy-to-handle hydrosilatrane as the reductant in direct reductive amination reactions. This efficient method enables a facile, metal-free access to secondary and tertiary amines from a wide range of aldehydes and ketones, with the synthesis of tertiary amines requiring no additives at all. This reaction demonstrates excellent functional group tolerance, chemoselectivity, and scalability. (Figure presented.).