60859-72-5Relevant academic research and scientific papers
Catalytic Enantioselective Synthesis of 3,4,5-Trisubstituted Isoxazoline N-Oxides and Regioselective Synthesis of 3,4,5-Trisubstituted Isoxazoles
Sahoo, Subas Chandra,Pan, Subhas Chandra
supporting information, p. 1385 - 1389 (2019/01/09)
An efficient catalytic asymmetric synthesis of 3,4,5-trisubstituted isoxazoline N-oxides and regioselective synthesis of 3,4,5-trisubstituted isoxazoles has been described. α-Nitrocinnamates and α-nitrobenzophenones were utilized as Michael acceptors resp
Direct aziridination of nitroalkenes affording N-alkyl-C-nitroaziridines and the subsequent Lewis acid mediated isomerization to β-nitroenamines
Hao, Feiyue,Asahara, Haruyasu,Nishiwaki, Nagatoshi
supporting information, p. 5442 - 5445 (2017/11/06)
A mild and highly diastereoselective one-pot synthesis of trans-N-alkyl-C-nitroaziridines was achieved by treatment of nitroalkenes with aliphatic amines and N-chlorosuccinimide. Treatment of the obtained aziridines with a Lewis acid resulted in a facile ring opening reaction, accompanied by rearrangement and isomerization into functionalized (Z)-β-nitroenamines.
Nucleophilic addition to nitroacrylates: application towards the synthesis of 2,3-dehydroamino acids and 2,3-diamino acids
Lewandowska, Elzbieta,Wichlacz, Kinga,Sobczak, Adam J.
body text, p. 152 - 156 (2010/03/01)
The addition of the N-pronucleophiles to 2- or 3-nitro-2-alkenoates in the presence of base provided Michael addition products. In the case of 3-nitro compounds, reaction occurred via the formation of α-adducts and the subsequent elimination of nitrous ac
Catalytic and asymmetric Friedel-Crafts alkylation of indoles with nitroacrylates. Application to the synthesis of tryptophan analogues
Sui, Yong,Liu, Li,Zhao, Jun-Ling,Wang, Dong,Chen, Yong-Jun
, p. 5173 - 5183 (2008/02/01)
An asymmetric Friedel-Crafts alkylation of indoles with nitroacrylates catalyzed by chiral (4R,5S)-DiPh-BOX (L1)-Cu(OTf)2 complex (10 mol %) has been developed. The reactions provide tryptophan nitro-precursors in moderate diastereoselectivitie
