99494-01-6

Basic information

• Product Name: N-Methyl-D-prolinol
• Synonyms: N-METHYL-D-PROLINOL;(R)-1-METHYL-2-PYRROLIDINEMETHANOL;(R)-(-)-(1-METHYL-2-PYRROLIDINYL)METHANOL;((R)-1-methylpyrrolidin-2-yl)methanol;[(2R)-1-Methylpyrrolidin-2-yl]Methanol;(R)-2-Hydroxymethyl-1-methylpyrrolidine
• CAS NO: 99494-01-6
• Molecular Formula: C₆H₁₃NO
• Molecular Weight: 115.17
• Mol File: 99494-01-6.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 164.8 °C at 760 mmHg
• Flash Point: 71℃
• Appearance: /
• Density: 0.971 g/mL at 25 °C
• Refractive Index: n20/D4.469
• Storage Temp.: 2-8°C
• PKA: 14.77±0.10(Predicted)
• CAS DataBase Reference: N-Methyl-D-prolinol(CAS DataBase Reference)
• NIST Chemistry Reference: N-Methyl-D-prolinol(99494-01-6)
• EPA Substance Registry System: N-Methyl-D-prolinol(99494-01-6)

Safety Data

• Hazard Codes: Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39
• RIDADR: NA 1993 / PGIII
• WGK Germany: 3
• Hazardous Substances Data: 99494-01-6(Hazardous Substances Data)

Usage

General Description

N-Methyl-D-prolinol, also known as NMPA, is a chiral auxiliary commonly used in organic synthesis as a catalyst and ligand in asymmetric reactions. It is a derivative of proline and has a methyl group attached to the nitrogen atom. NMPA has been widely used in the synthesis of pharmaceuticals and other complex organic molecules due to its ability to control the stereochemistry of reactions and improve the selectivity of various transformations. Its versatile nature and high efficiency make it a valuable tool in the field of organic chemistry, particularly in the production of chiral compounds. Additionally, NMPA has been reported to exhibit biological activities, including antitumor and antiviral properties, which further adds to its potential significance in drug discovery and development.

Upstream product

• 68078-09-1 N-methylproline 
• 68832-13-3 D-prolinol 
• 59378-81-3 1-(tert-butoxycarbonyl)prolin-2R-ol 
• 23356-96-9 (S)-1-Pyrrolidin-2-yl-methanol 
• 69610-40-8 N-(tert-butoxycarbonyl)-L-prolinol 
• 895160-34-6 (R)-pyrrolidine-1,2-dicarboxylic acid 2-tert-butyl ester 1-ethyl ester 
• 265660-44-4 (2S)-(+)-N-methyl-2-tributylstannylpyrrolidine 
• 344-25-2 D-Prolin 
• 74-88-4 methyl iodide 
• 175725-27-6 (R)-1-ethoxycarbonylprolin 
• 475-11-6 N-methyl-D-proline 

Downstream Products

• 1397922-62-1 (E)-N-[4-[[3-chloro-4-(2-pyridylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolyl]-3-[(2R)-1-methylpyrrolidin-2-yl]prop-2-enamide L-malate 
• 1397922-61-0 (E)-N-[4-[[3-chloro-4-(2-pyridylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolyl]-3-[(2R)-1-methylpyrrolidin-2-yl]prop-2-enamide maleate 
• 1397922-61-0 (R,E)-N-(4-(3-chloro-4-(pyridine-2-ylmethoxy)phenylamino)-3-cyano-7-ethoxyquinoline-6-yl)-3-(1-methylpyrrolidinyl-2-yl)acrylamide dimaleate salt 
• 1428555-18-3 C₂₁H₂₄BrF₃N₂O₅S 
• 1428555-25-2 C₁₃H₁₅F₃N₂O₃ 
• 1269662-77-2 (E)-N-[4-[(3-chloro-4-fluorophenyl)amino]-7-ethoxyquinazolin-6-yl]-3-[(2R)-1-methylpyrrolidin-2-yl]propan-2-enoylamine 
• 1269662-76-1 (E)-N-[4-[(3-chloro-4-fluorophenyl)amino]-7-(2-methoxyethoxy)quinazolin-6-yl]-3-[(2R )-1-methylpyrrolidin-2-yl]propan-2-enoylamine 
• 1269662-73-8 (E)-N-[4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-3-[(2R)-1-methylpyrrolidin-2-yl]propan-2-enoylamine 

Relevant articles and documents

FUMAGILLOL COMPOUNDS AND METHODS OF MAKING AND USING SAME

Disclosed herein, in part, are fumagillol compounds and methods of use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making fumagillol compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.

PHARMACEUTICALLY ACCEPTABLE SALT OF (E)-N-[4-[[3-CHLORO-4-(2-PYRIDYLMETHOXY)PHENYL]AMINO]-3-CYANO-7-ETHOXY-6-QUINOLYL]-3-[(2R)-1-METHYLPYRROLIDIN-2-YL]PROP-2-ENAMIDE, PREPARATION METHOD THEREFOR, AND MEDICAL USE THEREOF

Provided as represented by formula (I) is a pharmaceutically acceptable salt of (E)-N-[4-[[3-chloro-4-(2-pyridylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolyl] -3-[(2R)-1-methylpyrrolidin-2-yl]prop-2-enamide, a preparation method therefor, and a use thereof as a therapeutic agent and especially as a protein kinase inhibitor.

6-AMINO QUINAZOLINE OR 3-CYANO QUINOLINE DERIVATIVES, PREPARATION METHODS AND PHARMACEUTICAL USES THEREOF

6-amino quinazoline or 3-cyano quinoline derivatives, preparation methods and pharmaceutical uses thereof are disclosed. Specifically, the present disclosure discloses novel 6-amino quinazoline or 3-cyano quinoline derivatives presented by general formula (I), or tautomers, enantiomers, diastereomers, racemates or pharmaceutically acceptable salts thereof, or metabolites, metabolic precursors or prodrugs thereof, and their uses as treatment agents especially as protein kinase inhibitors, in which each substitutent group of general formula (I) is as defined in the specification.