99512-36-4Relevant academic research and scientific papers
Enol Lactone Inhibitors of Serine Proteases. The Effect of Regiochemistry on the Inactivation Behavior of Phenyl-Substituted (Halomethylene)tetra- and -dihydrofuranones and (Halomethylene)tetrahydropyranones toward α-Chymotrypsin: Stable Acyl Enzyme Inter
Sofia, Michael J.,Katzenellenbogen, John A.
, p. 230 - 238 (1986)
We have found that α-aryl-substituted halo enol lactones (I and II) are effective mechanism-based inactivators for chymotrypsin.In this study, we have investigated, for comparative purposes, halo enol lactones with aryl functions situated β and γ to the l
Palladium(0)-catalyzed alkynyl and allenyl iminium ion cyclizations leading to 1,4-disubstituted 1,2,3,6-tetrahydropyridines
Tsukamoto, Hirokazu,Kondo, Yoshinori
supporting information; experimental part, p. 4851 - 4854 (2009/02/08)
(Chemical Equation Presented) The biologically important title heterocyclic compounds can be synthesized by two methods based on the cyclization of alkynyl and allenyl iminium ions generated in situ in the presence of organometallic reagents (see scheme).
