Enol Lactone Inhibitors of Serine Proteases. The Effect of Regiochemistry on the Inactivation Behavior of Phenyl-Substituted (Halomethylene)tetra- and -dihydrofuranones and (Halomethylene)tetrahydropyranones toward α-Chymotrypsin: Stable Acyl Enzyme Inter

DOI: 10.1021/jm00152a011

Source and publish data:

Journal of Medicinal Chemistry p. 230 - 238 (1986)

Update date:2022-08-02

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Authors:

Sofia, Michael J.

Katzenellenbogen, John A.

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Article abstract of DOI:10.1021/jm00152a011

We have found that α-aryl-substituted halo enol lactones (I and II) are effective mechanism-based inactivators for chymotrypsin.In this study, we have investigated, for comparative purposes, halo enol lactones with aryl functions situated β and γ to the l

Full text of DOI:10.1021/jm00152a011

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