Enol Lactone Inhibitors of Serine Proteases. The Effect of Regiochemistry on the Inactivation Behavior of Phenyl-Substituted (Halomethylene)tetra- and -dihydrofuranones and (Halomethylene)tetrahydropyranones toward α-Chymotrypsin: Stable Acyl Enzyme Inter

DOI: 10.1021/jm00152a011

Source and publish data:

Journal of Medicinal Chemistry p. 230 - 238 (1986)

Update date:2022-08-02

Topics:

Authors:

Sofia, Michael J.

Katzenellenbogen, John A.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00152a011

We have found that α-aryl-substituted halo enol lactones (I and II) are effective mechanism-based inactivators for chymotrypsin.In this study, we have investigated, for comparative purposes, halo enol lactones with aryl functions situated β and γ to the l

Full text of DOI:10.1021/jm00152a011

Products guided by the article

Product name:Methanesulfonic acid 1-phenyl-but-3-ynyl ester

Cas No:99512-36-4

R&D Labs maybe for 99512-36-4

Zhangjiagang Jianing Import & Export Co.,Ltd.

Contact:086-512-55379012 13913607595

Address:NO.1 Guotai North Road Zhangjiagang Economic Development Zone,215600,Jiangsu,China
Okeanos Tech.Co.,LTD

Contact:+86-10-62651721

Address:29 Yongxing Road, Daxing District,Beijing China
He Bei Shun Er Chemical Co., LTD.

Contact:86-0311-86996932/86860168

Address:No 18,North street
Changyi Xinxing Technology Development Co., Ltd.

Contact:0086-510-86651065(Time Zone:8),86651656

Address:94 Yingbinxilu WestRoad, Huangtu Town, Jiangyin City, Jiangsu, China
Forsman Scientific(Beijing)co.,Ltd.

Contact:+86-10-64646565

Address:Rm No.1301, Building-2, No. A-13 Beiyuan Road, Chaoyang District Beijing, China, PR,

Relevant to this article

Improved synthesis of indirubin derivatives by sequential build-up of the indoxyl unit: First preparation of fluorescent indirubins

Doi:10.1002/hlca.201200042
(2012)
Doi:10.1055/s-1973-22291
(1973)
Complexing ability of the versatile, redox-active, 3-[3-(diphenylphosphino)propylthio]-3′,4,4′-trimethyl- tetrathiafulvalene ligand

Doi:10.1021/ic026186f
(2003)
N-sulfinyl beta-amino Weinreb amides: synthesis of enantiopure beta-amino carbonyl compounds. Asymmetric synthesis of (+)-sedridine and (-)-allosedridine.

Doi:10.1021/ol034119z
(2003)
Doi:10.1021/ja00804a021
(1973)
The synthesis of mono- and difluorinated 2,3-dideoxy-d-glucopyranoses

Doi:10.1016/j.jfluchem.2014.08.023
(2015)

Article Doi