Enol Lactone Inhibitors of Serine Proteases. The Effect of Regiochemistry on the Inactivation Behavior of Phenyl-Substituted (Halomethylene)tetra- and -dihydrofuranones and (Halomethylene)tetrahydropyranones toward α-Chymotrypsin: Stable Acyl Enzyme Inter

Article abstract of DOI:10.1021/jm00152a011

We have found that α-aryl-substituted halo enol lactones (I and II) are effective mechanism-based inactivators for chymotrypsin.In this study, we have investigated, for comparative purposes, halo enol lactones with aryl functions situated β and γ to the l