99532-46-4

Basic information

• Product Name: 1-[1-(benzenesulfonyl)-6-methoxy-indol-3-yl]ethanone
• Synonyms: 1-[6-Methoxy-1-(phenylsulfonyl)-1H-indol-3-yl]ethanone; ethanone, 1-[6-methoxy-1-(phenylsulfonyl)-1H-indol-3-yl]-
• CAS NO: 99532-46-4
• Molecular Formula: C₁₇H₁₅NO₄S
• Molecular Weight: 329.3703
• Mol File: 99532-46-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 540.004°C at 760 mmHg
• Flash Point: 280.385°C
• Density: 1.298g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.617
• CAS DataBase Reference: 1-[1-(benzenesulfonyl)-6-methoxy-indol-3-yl]ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[1-(benzenesulfonyl)-6-methoxy-indol-3-yl]ethanone(99532-46-4)
• EPA Substance Registry System: 1-[1-(benzenesulfonyl)-6-methoxy-indol-3-yl]ethanone(99532-46-4)

Safety Data

• Hazardous Substances Data: 99532-46-4(Hazardous Substances Data)

Usage

General Description

1-[1-(benzenesulfonyl)-6-methoxy-indol-3-yl]ethanone is a compound with a chemical structure consisting of a sulfonamide group attached to a methoxy-indole and an ethanone moiety. The benzenesulfonyl group is a benzene ring with a sulfonamide functional group, which is known for its reactivity towards nucleophiles. The methoxy-indole group is a derivative of indole, which is a heterocyclic compound found in many natural products and pharmaceuticals. The ethanone moiety is a ketone functional group, which is involved in various organic reactions. 1-[1-(benzenesulfonyl)-6-methoxy-indol-3-yl]ethanone may have potential applications in medicinal chemistry and drug development due to its unique chemical structure and properties.

Upstream product

• 56995-13-2 6-methoxy-1-(phenylsulfonyl)-1H-indole 
• 108-24-7 acetic anhydride 
• 3189-13-7 6-methoxylindole 
• 1082892-90-7 3-(6-methoxy-1H-indol-3-yl)-3-oxopropanenitrile 
• 98-09-9 benzenesulfonyl chloride 
• 99532-52-2 1-(6-methoxy-1H-indol-3-yl)ethan-1-one 
• 99546-93-7 N-(2,2-diethoxyethyl)-N-(3-methoxyphenyl)-benzene-sulfonamide 
• 32431-44-0 2-(3-methoxyanilino)acetaldehyde diethyl acetal 

Downstream Products

• 1371572-77-8 C₁₇H₁₇NO₄S 
• 99532-52-2 1-(6-methoxy-1H-indol-3-yl)ethan-1-one 

Relevant articles and documents

Indole compound and applications thereof, and pharmaceutical composition and applications thereof

The present invention provides an indole compound and applications thereof, wherein the compound can effectively inhibit a CBP/EP300 Bromodomain receptor, and can be used as a drug for cancers, inflammatory diseases, autoimmune diseases, septicemia and viral infections.

Novel and simple methodology for the synthesis of 3-acetylindoles and their N-alkyl derivatives using TBAB as phase transfer catalyst

Using 5% aq. NaOH, a simple method for the transformation of 3-cyanoacetylindoles 2(a-e) into 3-acetylindoles 3 (a-e), in good yields, is reported. Tetrabutylammoniumbromide (TBAB) is found to be an efficient phase transfer catalyst for the synthesis of N-alkyl derivatives 5(a-t) of 3-acetylindoles 3(a-e) giving products in excellent yields. 2 (a-e) were themselves obtained from simple indoles 1 (a-e) by reaction with cyano acetic acid in the presence of propionic anhydride at 100 °C for 5-10 min. Partial hydrolysis of 2 (a-e) under hot acidic conditions yielded the corresponding carboxamides α-(3-indolecarboxoyl)acetamides 4(a-e). Which could be readily transformed into the respective 3(a-e) by refluxing with 5% aq. NaOH for 2-2.5 h.