99563-82-3Relevant academic research and scientific papers
HETEROCYCLIC COMPOUNDS AND USE OF SAME
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, (2016/01/08)
Novel heterocyclic compounds are provided which display useful efficacy in the treatment of diseases caused by trypanosomatids. Particularly, the compounds of the invention are useful in the treatment of HAT and/or Chagas disease and/or Animal African trypanosomiasis (AAT).
Efficient, mild and completely regioselective synthesis of substituted pyridines
Andersson, Hans,Sainte-Luce Banchelin, Thomas,Das, Sajal,Olsson, Roger,Almqvist, Fredrik
supporting information; experimental part, p. 3384 - 3386 (2010/07/06)
Addition of Grignard reagents to pyridine N-oxides in THF at low temperature (-78 to -20 °C) and treatment with TFAA provides an efficient general procedure for synthesis of substituted pyridines. The method is compatible with a range of functional groups such as esters, halogens and nitriles.
Branch-selective reductive coupling of 2-vinyl pyridines and imines via rhodium catalyzed C-C bond forming hydrogenation
Komanduri, Venukrishnan,Grant, Christopher D.,Krische, Michael J.
supporting information; experimental part, p. 12592 - 12593 (2009/05/08)
Hydrogenation of 2-vinyl azines 1a-1e in the presence of N-arylsulfonyl imines 2a-2l at ambient temperature and pressure employing cationic rhodium catalysts ligated by tri-2-furylphosphine results in regioselective reductive coupling to furnish branched
REGIOSELECTIVE SYNTHESIS OF 2-SUBSTITUTED PYRIDINES VIA GRIGNARD ADDITION TO 1-(ALKOXYCARBOXY)-PYRIDINIUM SALTS
Webb, Thomas R.
, p. 3191 - 3194 (2007/10/02)
A regioselective one pot synthesis of 2-substituted pyridine derivatives from pyridine-1-oxides is described.
