99578-59-3

Upstream product

• 98-80-6 phenylboronic acid 
• 122-78-1 phenylacetaldehyde 
• 4815-34-3 ethyl 2-amino-5-phenylthiophene-3-carboxylate 
• 100523-84-0 2-bromothiophene-4-carboxylic acid 
• 99578-58-2 5-phenyl-thiophene-3-carboxylic acid 

Downstream Products

• 1187466-41-6 (5-phenyl-thiophen-3-yl)-pyrrolidin-1-yl-methanone 

Relevant academic research and scientific papers

AMIDO-THIOPHENE COMPOUNDS AND THEIR USE

The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain amido-thiophene compounds that, inter alia, inhibit 11 β-hydroxysteroid dehydrogenase type 1 (11 β-HSD1 ). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit 11 β-hydroxysteroid dehydrogenase type 1; to treat disorders that are ameliorated by the inhibition of 11 β-hydroxysteroid dehydrogenase type 1; to treat the metabolic syndrome, which includes disorders such as type 2 diabetes and obesity, and associated disorders including insulin resistance, hypertension, lipid disorders and cardiovascular disorders such as ischaemic (coronary) heart disease; to treat CNS disorders such as mild cognitive impairment and early dementia, including Alzheimer's disease; etc.