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Usage

Uses

Used in Pharmaceutical Industry:
5-Phenyl-3-thiophenecarboxylic acid is used as a building block for the synthesis of complex molecules in the pharmaceutical industry. Its unique structure and functional groups make it a valuable component in the development of new drugs.
Used in Organic Synthesis:
5-Phenyl-3-thiophenecarboxylic acid is used as a key intermediate in organic synthesis for the preparation of various organic compounds. Its versatility and reactivity make it a popular choice for chemists working on the synthesis of novel molecules.
Used in Agrochemical Industry:
5-Phenyl-3-thiophenecarboxylic acid is used as an intermediate in the synthesis of agrochemicals, such as pesticides and herbicides. Its potential applications in this industry contribute to the development of more effective and environmentally friendly products.
Used in Research and Development:
5-Phenyl-3-thiophenecarboxylic acid is used as a research compound in the study of its pharmacological properties, such as anti-inflammatory and antifungal activities. This research can lead to the discovery of new therapeutic agents and applications in medicine.
Used in Drug Delivery Systems:
5-Phenyl-3-thiophenecarboxylic acid can be used in the development of drug delivery systems to improve the bioavailability and therapeutic efficacy of various pharmaceuticals. Its unique chemical properties make it a promising candidate for the design of novel drug delivery platforms.

Upstream product

• 122-78-1 phenylacetaldehyde 
• 4815-34-3 ethyl 2-amino-5-phenylthiophene-3-carboxylate 
• 100523-84-0 2-bromothiophene-4-carboxylic acid 
• 98-80-6 phenylboronic acid 
• 38695-72-6 methyl 5-phenylthiophene-3-carboxylate 

Downstream Products

• 1187466-35-8 (2-methyl-piperidin-1-yl)-(5-phenyl-thiophen-3-yl)-methanone 
• 1187466-31-4 1-[4-(5-phenyl-thiophene-3-carbonyl)-[1,4]diazepan-1-yl]-ethanone 
• 1187467-75-9 (4,4-difluoro-azepan-1-yl)-(5-phenyl-thiophen-3-yl)-methanone 
• 99578-59-3 C₁₁H₇ClOS 
• 1187467-76-0 (2-chloro-5-phenyl-thiophen-3-yl)-(4,4-difluoro-azepan-1-yl)-methanone 
• 1187466-41-6 (5-phenyl-thiophen-3-yl)-pyrrolidin-1-yl-methanone 
• 1414873-67-8 C₂₄H₂₅N₅OS 
• 1311195-96-6 (5-phenylthiophen-3-yl)(3,4,5-trimethoxyphenyl)methanol 
• 1311195-63-7 (5-phenylthiophen-3-yl)(3,4,5-trimethoxyphenyl)methanone 
• 38115-12-7 5-phenylthiophene-3-carboxaldehyde 
• 1311195-94-4 N-methoxy-N-methyl-5-phenylthiophene-3-carboxamide 

Relevant academic research and scientific papers

Synthesis and Pharmacological Evaluation of 1-Phenyl-3-Thiophenylurea Derivatives as Cannabinoid Type-1 Receptor Allosteric Modulators

We previously reported diarylurea derivatives as cannabinoid type-1 receptor (CB1) allosteric modulators, which were effective in attenuating cocaine-seeking behavior. Herein, we extended the structure-activity relationships of PSNCBAM-1 (2) at the central phenyl ring directly connected to the urea moiety. Replacement with a thiophene ring led to 11 with improved or comparable potencies in calcium mobilization, [35S]GTPγS binding, and cAMP assays, whereas substitution with nonaromatic rings led to significant attenuation of the modulatory activity. These compounds had no inverse agonism in [35S]GTPγS binding, a characteristic that is often thought to contribute to adverse psychiatric effects. While 11 had good metabolic stability in rat liver microsomes, it showed modest solubility and blood-brain barrier permeability. Compound 11 showed an insignificant attenuation of cocaine seeking behavior in rats, most likely due to its limited CNS penetration, suggesting that pharmacokinetics and distribution play a role in translating the in vitro efficacy to in vivo behavior.

Rhodium Thiavinyl Carbenes from 1,2,3-Thiadiazoles Enable Modular Synthesis of Multisubstituted Thiophenes

The rhodium-catalyzed transannulation reaction between 1,2,3-thiadiazoles and alkynes, proceeding via intermediacy of the previously unknown Rh thiavinyl carbene, toward a highly efficient and regioselective synthesis of up to fully substituted thiophenes is described.

AMIDO-THIOPHENE COMPOUNDS AND THEIR USE

The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain amido-thiophene compounds that, inter alia, inhibit 11 β-hydroxysteroid dehydrogenase type 1 (11 β-HSD1 ). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit 11 β-hydroxysteroid dehydrogenase type 1; to treat disorders that are ameliorated by the inhibition of 11 β-hydroxysteroid dehydrogenase type 1; to treat the metabolic syndrome, which includes disorders such as type 2 diabetes and obesity, and associated disorders including insulin resistance, hypertension, lipid disorders and cardiovascular disorders such as ischaemic (coronary) heart disease; to treat CNS disorders such as mild cognitive impairment and early dementia, including Alzheimer's disease; etc.

Synthesis and structure-activity relationships of 5-phenylthiophenecarboxylic acid derivatives as antirheumatic agents

5-(Phenylthiophene)-3-carboxylic acid (2a), a metabolite of esonarimod (1), which was developed as a new antirheumatic drug, was considered as a lead compound for new antirheumatic drugs. A new series of 2a derivatives were synthesized and their characteristic pharmacological effects, that is their antagonistic effect toward interleukin (IL)-1 in mice and the suppressive effect against adjuvant-induced arthritis (AIA) in rats, were evaluated and compared with those of 1. The structure-activity relationships indicated that [5-(4-bromophenyl)-thiophen-3-yl]acetic acid (5d), methyl [5-(4-chlorophenyl)-thiophen-3-yl]acetate (5h), and methyl [5-(4-bromophenyl)-thiophen-3-yl]acetate (5i) suppressed AIA more potently than 1 and all of the other synthesized compounds.