99705-03-0Relevant academic research and scientific papers
Selective β3-Adrenergic Agonists of Brown Adipose Tissue and Thermogenesis. 1. ethoxy>phenoxy>acetates
Howe, Ralph,Rao, Balbir S.,Holloway, Brian R.,Stribling, Donald
, p. 1751 - 1759 (2007/10/02)
The ester methyl ethoxy>phenoxy>acetate (8) has been identified as the most interesting member of a series of selective β3-adrenergic agonists of brown adipose tissue and thermogenesis in the rat.In vivo
Phenoxypropanolamines and pharmaceutical use
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, (2008/06/13)
Tertiary and secondary amines of the formulas STR1 wherein n is the integer 1 or 2, p0 R is hydrogen, lower-alkanoyl or phenyl-lower-alkanoyl, X1 is phenoxymethyl optionally mono-fluorinated or mono-chlorinated in the ortho-position, X2 is lower-alkyl, phenoxymethyl optionally mono-fluorinated or mono-chlorinated in the ortho-position or phenyl optionally monosubstituted by fluorine, chlorine, trifluoromethyl or lower-alkoxy, Y is hydrogen or methyl, and Z is a phenyl or thienyl residue substituted as hereinafter described, and the physiologically and pharmaceutically compatible salts are described. The compounds of formulas I and V-1 have catabolic activity and can be used for the treatment of obesity and diabetes mellitus or for the treatment of conditions which are associated with an increased protein breakdown, or as feed additives for fattening animals. The compounds of formulas I and V-1 can be prepared starting from corresponding primary amines.
