4287-19-8

Basic information

• Product Name: 1-AMINO-3-PHENOXY-PROPAN-2-OL
• Synonyms: 1-AMINO-3-PHENOXY-2-PROPANOL;1-AMINO-3-PHENOXY-PROPAN-2-OL;IFLAB-BB F1995-0008;TIMTEC-BB SBB010049;2-Propanol, 1-amino-3-phenoxy-
• CAS NO: 4287-19-8
• Molecular Formula: C₉H₁₃NO₂
• Molecular Weight: 167.21
• Product Categories: pharmacetical
• Mol File: 4287-19-8.mol
• Article Data: 12

Chemical Properties

• Melting Point: 145 - 147 ºC
• Boiling Point: 330.2 °C at 760 mmHg
• Flash Point: 153.5 °C
• Appearance: white powder
• Density: 1.129 g/cm³
• Water Solubility: soluble in water
• CAS DataBase Reference: 1-AMINO-3-PHENOXY-PROPAN-2-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 1-AMINO-3-PHENOXY-PROPAN-2-OL(4287-19-8)
• EPA Substance Registry System: 1-AMINO-3-PHENOXY-PROPAN-2-OL(4287-19-8)

Safety Data

• Hazard Codes: Xi
• Statements: R21 R22 R34 R37 R38 R41:
• Safety Statements: S25 S28a S36 S37 S39 S45:
• HazardClass: IRRITANT
• Hazardous Substances Data: 4287-19-8(Hazardous Substances Data)

Usage

General Description

1-AMINO-3-PHENOXY-PROPAN-2-OL is a chemical compound with the molecular formula C9H13NO2. It is a colorless to pale yellow liquid that is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals. It is also used as a building block in the production of various organic compounds. This chemical has a wide range of applications in the chemical industry due to its versatility and reactivity. Its properties make it valuable in the development of new materials and products across a variety of industries.

Upstream product

• 122-60-1 Phenyl glycidyl ether 
• 86809-23-6 l-1-Phenoxy-2-hydroxy-3-ammoniumpropane-L-pantoate 
• 86809-23-6 d-1-Phenoxy-2-hydroxy-3-ammoniumpropane-D-pantoate 
• 121282-65-3 1-azido-3-phenoxypropan-2-ol 
• 119047-03-9 (S)-2-((R)-1-Methyl-3-oxo-butoxy)-3-phenoxy-propionitrile 
• 119046-98-9 (S)-2-((1R,3R)-3-Hydroxy-1-methyl-butoxy)-3-phenoxy-propionitrile 
• 119046-95-6 (4R,6R)-4,6-Dimethyl-2-phenoxymethyl-[1,3]dioxane 
• 32438-31-6 (2,2-diethoxy-ethoxy)-benzene 
• 7664-41-7 ammonia 
• 189163-30-2 1-N-(trifluoroacetyl)-3-(phenoxy)propan-2-ol 
• 32968-43-7 5-(phenoxymethyl)-2-amino-2-oxazoline 
• 119047-07-3 phenoxyacetaldehyde cyanohydrin 
• 4769-73-7 (RS)-1-chloro-3-phenyloxy-2-propanol 

Downstream Products

• 32599-04-5 1-phenoxy-3-(piperidin-1-yl)propan-2-ol 
• 60523-64-0 2,2,2-Trichloro-N-(2-hydroxy-3-phenoxy-propyl)-acetamidine 
• 73823-47-9 3-(β-Hydroxy-γ-phenoxypropylimino)quinuclidine 
• 7695-63-8 (+/-)-1-isopropylamino-3-phenoxypropan-2-ol 
• 560109-18-4 3-chloro-6-[(2-hydroxy-3-phenoxy-propyl)amino]pyridazine 
• 19111-20-7 5-(phenoxymethyl)-oxazolidin-2-one 
• 81732-03-8 1-(2-Chloroacetamido)-3-phenoxypropan-2-ol 
• 103434-30-6 dimethyl 4-[2-[4-[[(S)-2-hydroxy-3phenoxypropyl]amino]butoxy]-5-nitrophenyl]-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate 
• 929548-38-9 (2R,3R,3aS,6R,6aR,3'R,3'aS,6'R,6'aR,5''R)-spiro[6,3',6'-trihydroxy-octahydro[2,3']bi[furo[3,2-b]furan]-3,2''-[5''-phenoxymethyl-1'',3''-oxazolidine]] 
• 112243-65-9 (S)-2-hydroxy-3-phenoxypropylamine 
• 1311966-86-5 C₁₉H₂₇NO₅ 
• 1202159-14-5 C₁₆H₁₇N₃O₆ 
• 403860-21-9 2-Amino-N-(2-hydroxy-3-phenoxypropyl)acetamide 
• 139734-40-0 methyl 2-p-(2-[(2-hydroxy-3-phenoxypropyl)amino]propoxy)-phenoxyacetate 

Relevant articles and documents

A waste-minimized protocol for the preparation of 1,2-azido alcohols and 1,2-amino alcohols

Under solvent-free conditions the reaction of epoxides 1a-i with trimethylsilylazide (2) catalyzed by polystiryl-supported fluoride (PS-DABCOF2) has led to the efficient preparation of the corresponding O-TMS protected 1,2-azido alcohols 3a-i that, by treatment with Dowex-H, gave the related 1,2-azido alcohols 4a-i in excellent yields (83-99% and 82-96%, respectively). The use of a flow procedure has allowed us to significantly minimize waste in the preparation of representative 1,2-azido alcohols 4a, 4c and 4i that have been obtained with E-factors of 1.6, 2.1, and 1.9, respectively. The 1,2-amino alcohols 5a, 5c and 5f have been also prepared, in quantitative yields, by reduction of the corresponding O-TMS protected 1,2-azido alcohols 3a, 3c, and 3f by Pd on the Al2O3/HCOOH system.

Non-enzymatic kinetic resolution of β-amino alcohols using C-12 higher carbon sugar as a chiral auxiliary

An efficient non-enzymatic kinetic resolution strategy capable of accessing optically active β-adrenergic antagonists intermediates is reported. The C-12 higher carbon sugar derived from naturally occurring sucrose was employed to probe the kinetic resolution. Excellent enantiomeric excesses (ee >99%) and high yields were obtained under very mild conditions. The chiral auxiliary could be recovered in a high reclaimed ratio (>95%) and reusable form without any decrease of the resolving ability.

A General Route to the Synthesis of N-Protected 1-Substituted and 1,2-Disubstituted Taurines

N-Benzyloxycarbonyl protected α-substituted and αβ- disubstituted taurines were synthesized from olefins and epoxides via N-benzyloxycarbonylamino alcohol thioacetates as key intermediates. They are important sulfur analogues of naturally occurring amino acids and building blocks for the synthesis of α-substituted and α,β- disubstituted β-sulfonopeptides.