4287-19-8

Usage

Uses

Used in Pharmaceutical Industry:
1-AMINO-3-PHENOXY-PROPAN-2-OL is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to react and form new compounds that possess therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical sector, 1-AMINO-3-PHENOXY-PROPAN-2-OL is utilized as a precursor in the production of agrochemicals, contributing to the development of effective solutions for crop protection and enhancement.
Used in Specialty Chemicals Production:
1-AMINO-3-PHENOXY-PROPAN-2-OL is employed as a building block in the creation of specialty chemicals, where its unique properties allow for the formulation of high-performance products tailored for specific applications.
Used in Chemical Research and Development:
1-AMINO-3-PHENOXY-PROPAN-2-OL is also used as a research tool in the development of new materials and products, where its reactivity and versatility are harnessed to explore novel chemical reactions and syntheses.

Upstream product

• 122-60-1 Phenyl glycidyl ether 
• 119046-98-9 (S)-2-((1R,3R)-3-Hydroxy-1-methyl-butoxy)-3-phenoxy-propionitrile 
• 119047-03-9 (S)-2-((R)-1-Methyl-3-oxo-butoxy)-3-phenoxy-propionitrile 
• 86809-23-6 l-1-Phenoxy-2-hydroxy-3-ammoniumpropane-L-pantoate 
• 86809-23-6 d-1-Phenoxy-2-hydroxy-3-ammoniumpropane-D-pantoate 
• 121282-65-3 1-azido-3-phenoxypropan-2-ol 
• 119046-95-6 (4R,6R)-4,6-Dimethyl-2-phenoxymethyl-[1,3]dioxane 
• 32438-31-6 (2,2-diethoxy-ethoxy)-benzene 
• 7664-41-7 ammonia 
• 189163-30-2 1-N-(trifluoroacetyl)-3-(phenoxy)propan-2-ol 
• 32968-43-7 5-(phenoxymethyl)-2-amino-2-oxazoline 
• 4769-73-7 (RS)-1-chloro-3-phenyloxy-2-propanol 
• 119047-07-3 phenoxyacetaldehyde cyanohydrin 

Downstream Products

• 73823-47-9 3-(β-Hydroxy-γ-phenoxypropylimino)quinuclidine 
• 25409-57-8 N-(3-Phenoxy-2-oxypropyl)-N'-phenylthiourea 
• 112169-43-4 N-(p-Aminobenzoyl)-3-phenoxy-2-oxypropylamine 
• 403860-21-9 2-Amino-N-(2-hydroxy-3-phenoxypropyl)acetamide 
• 28997-07-1 2-(γ-phenoxy-β-hydroxypropyl)aminobenzothiazole 
• 32968-43-7 5-(phenoxymethyl)-2-amino-2-oxazoline 
• 1311966-86-5 C₁₉H₂₇NO₅ 
• 1202159-14-5 C₁₆H₁₇N₃O₆ 
• 929548-38-9 (2R,3R,3aS,6R,6aR,3'R,3'aS,6'R,6'aR,5''R)-spiro[6,3',6'-trihydroxy-octahydro[2,3']bi[furo[3,2-b]furan]-3,2''-[5''-phenoxymethyl-1'',3''-oxazolidine]] 
• 112243-65-9 (S)-2-hydroxy-3-phenoxypropylamine 
• 103434-30-6 dimethyl 4-[2-[4-[[(S)-2-hydroxy-3phenoxypropyl]amino]butoxy]-5-nitrophenyl]-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate 
• 81732-03-8 1-(2-Chloroacetamido)-3-phenoxypropan-2-ol 
• 139734-40-0 methyl 2-p-(2-[(2-hydroxy-3-phenoxypropyl)amino]propoxy)-phenoxyacetate 
• 19111-20-7 5-(phenoxymethyl)-oxazolidin-2-one 

Relevant academic research and scientific papers

A waste-minimized protocol for the preparation of 1,2-azido alcohols and 1,2-amino alcohols

Under solvent-free conditions the reaction of epoxides 1a-i with trimethylsilylazide (2) catalyzed by polystiryl-supported fluoride (PS-DABCOF2) has led to the efficient preparation of the corresponding O-TMS protected 1,2-azido alcohols 3a-i that, by treatment with Dowex-H, gave the related 1,2-azido alcohols 4a-i in excellent yields (83-99% and 82-96%, respectively). The use of a flow procedure has allowed us to significantly minimize waste in the preparation of representative 1,2-azido alcohols 4a, 4c and 4i that have been obtained with E-factors of 1.6, 2.1, and 1.9, respectively. The 1,2-amino alcohols 5a, 5c and 5f have been also prepared, in quantitative yields, by reduction of the corresponding O-TMS protected 1,2-azido alcohols 3a, 3c, and 3f by Pd on the Al2O3/HCOOH system.

Regio-selective synthesis of 1,2-aminoalcohols from epoxides and chlorohydrins

A simple and efficient procedure for the regio-selective synthesis of 1,2-aminoalcohols from terminal epoxides and chlorohydrins by using NaHMDS as the source of amine is reported. The wider scope and utility of this method is demonstrated.

Non-enzymatic kinetic resolution of β-amino alcohols using C-12 higher carbon sugar as a chiral auxiliary

An efficient non-enzymatic kinetic resolution strategy capable of accessing optically active β-adrenergic antagonists intermediates is reported. The C-12 higher carbon sugar derived from naturally occurring sucrose was employed to probe the kinetic resolution. Excellent enantiomeric excesses (ee >99%) and high yields were obtained under very mild conditions. The chiral auxiliary could be recovered in a high reclaimed ratio (>95%) and reusable form without any decrease of the resolving ability.

CARBOXAMIDE DERIVATIVE

An SGLT inhibitor comprising a compound of the formula: (|) wherein the ring A is an optionally substituted ring; R1 is an optionally substituted hydrocarbon group, etc.; each of R2 and R3 independently is a hydrogen atom, an optionally substituted hydrocarbon group, etc.; R4 is an optionally substituted hydrocarbon group, etc.; and X is a bivalent chain group whose main chain consists of 1 to 6 atoms. This SGLT inhibitor is useful as a preventive/therapeutic agent for diabetes mellitus, obesity, hypertension, hyperlipemia, etc.

A General Route to the Synthesis of N-Protected 1-Substituted and 1,2-Disubstituted Taurines

N-Benzyloxycarbonyl protected α-substituted and αβ- disubstituted taurines were synthesized from olefins and epoxides via N-benzyloxycarbonylamino alcohol thioacetates as key intermediates. They are important sulfur analogues of naturally occurring amino acids and building blocks for the synthesis of α-substituted and α,β- disubstituted β-sulfonopeptides.

Regioselective opening of epoxides to β-amido alcohols under solid-liquid PTC conditions

A study on the ring opening of a number of epoxides 1 with trifluoroacetamide (2) under solid-liquid phase transfer catalysis (SL-PTC) conditions has been performed. The reaction is completely regioselective affording β-amido alcohols 3 deriving from the attack of the nucleophile to the less substituted carbon atom of the oxirane ring.

Thiazolidine and oxazolidine derivatives, their preparation and their medical use

Compounds of formula (I): STR1 and salts, esters and solyates thereof and pro-drugs therefor are useful for the treatment and/or prophylaxis of a variety of disorders, including one or more of: hyperlipemia, hyperglycemia, obesity, glucose tolerance insufficiency, insulin resistance and diabetic complications.

Synthesis and psychotrope evaluation of new 3-ureidopropan-2-ols using the skin conductance reaction (SCR)-habituation test

The syntheses of 1-substituted 3-ureidopropan-2-ols 2 and 3-acetyl-5-(phenyl-4-piperazinyl)methyl-2-oxazolidinones 5 from the corresponding 2-amino-2 oxazolines 1 are described. Some of these compounds have been investigated for psychotropic activity in m

TiCl4 Induced Opening of Chiral Acetals: a route to β-adrenergic blocking agents

Aryloxy and alkyloxypropanolamines 7a-c are obtained in 45 to 70 percent yields and with asymmetric induction, using TiCl4 induced nucleophilic addition of cyanotrimethylsilane onto chiral acetals derived from racemic 2,4-pentanediol.Therefore, optically pure 2,4-pentanediol will provide, after a purification, optically pure 7a-c.