99723-34-9Relevant academic research and scientific papers
Baker's yeast-mediated regioselective reduction of 2,4-dinitroacylanilines: Synthesis of 2-substituted 6-nitrobenzimidazoles
Olguín, Luís F.,Jiménez-Estrada, Manuel,Bárzana, Eduardo,Navarro-Oca?a, Arturo
, p. 340 - 342 (2007/10/03)
Several 2,4-dinitro-N-acylanilines were regioselectively reduced at the C-2 position by baker's yeast in slightly basic media (pH = 7.5) to afford 2-amino-4-nitroacylanilines, which were then cyclized under acidic conditions to the corresponding 2-substituted-6-nitrobenzimidazoles. The benzimidazoles thus obtained can be employed as precursors for bioactive derivatives.
