623-66-5Relevant articles and documents
One-pot electrochemical synthesis of acid anhydrides from alcohols
Kashparova,Papina,Kashparov,Zhukova, I. Yu.,Ilchibaeva,Kagan, E. Sh.
, p. 2733 - 2735 (2017/12/26)
One-pot indirect electrochemical oxidation of alcohols in the methylene chloride–aqueous solution of sodium hydrocarbonate two-phase system in the presence of potassium iodide, 4-acetylamino-2,2,6,6-tetramethylpiperidin-1-oxyl, and 2,6-lutidine results in
Elucidation of the topography of the thapsigargin binding site in the sarco-endoplasmic calcium ATPase
Skytte, Dorthe Mondrup,Moller, Jesper Vuust,Liu, Huizhen,Nielsen, Helle stergren,Svenningsen, Louise Elsa,Jensen, Christina Mernoe,Olsen, Carl Erik,Christensen, Soren Brogger
experimental part, p. 5634 - 5646 (2010/09/14)
Removal of each of the acyl groups of thapsigargin at O-3, O-8 and O-10 significant reduces the affinity of the inhibitors to the SERCA1a pump. Replacement of the acyl groups at O-3 and O-10 with flexible residues could be performed with only a minor decrease of the affinity, whereas introduction of voluminous stiff residues caused dramatic reduction of the affinity. The results can be rationalized on the basis of the interactions of thapsigargin with the SERCA1a pump as revealed from 3D X-ray structural models of thapsigargin bound to the SERCA1a. In conclusion the results confirm and elaborate the previously suggested pharmocophore model of thapsigargin.
Identification of a tunable site in bryostatin analogs: C20 bryologs through late stage diversification
Wender, Paul A.,Baryza, Jeremy L.
, p. 1177 - 1180 (2007/10/03)
The C20 region of our bryostatin analogs was identified as a nonpharmacophoric site that could be varied to tune analogs for function and physical properties without significantly affecting their binding affinity for PKC. The use of this site in a late-stage diversification strategy has enabled the facile synthesis of a variety of new C20 analogs, all of which retain nanomolar affinity for PKC, in agreement with our pharmacophore hypothesis.