99735-30-5

Usage

Uses

Used in Pharmaceutical Industry:
1-BENZYL-3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE is used as a building block for the synthesis of various pharmaceuticals due to its ability to contribute to the formation of complex molecular structures that can exhibit therapeutic effects.
Used in Agrochemical Industry:
Similarly, in the agrochemical sector, 1-BENZYL-3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE serves as a fundamental component in the development of compounds designed to protect crops and enhance agricultural productivity.
Used as a Protecting Group for Amines:
In organic chemistry, 1-BENZYL-3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE is utilized as a protecting group for amines, which is crucial for preventing unwanted side reactions during the synthesis process, thereby ensuring the purity and functionality of the final product.
Used as a Precursor in Drug Synthesis:
1-BENZYL-3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE also acts as a precursor in the synthesis of pharmaceutical drugs, indicating its importance in the early stages of drug development, where it can influence the properties and effectiveness of the resulting medication.
Used in Medicinal Research:
The unique chemical structure of 1-BENZYL-3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE has attracted attention in medicinal research for its potential applications in developing new drugs for a variety of therapeutic purposes, highlighting its significance in advancing medical treatments.

InChI:InChI=1/C16H24N2O2/c1-16(2,3)20-15(19)17-14-9-10-18(12-14)11-13-7-5-4-6-8-13/h4-8,14H,9-12H2,1-3H3,(H,17,19)

Upstream product

• 18471-40-4 1-Benzyl-3-aminopyrrolidine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 100-39-0 benzyl bromide 
• 99724-19-3 3-(tert-butoxycarbonylamino)pyrrolidine 

Downstream Products

• 99724-19-3 3-(tert-butoxycarbonylamino)pyrrolidine 
• 18471-40-4 1-Benzyl-3-aminopyrrolidine 

Relevant academic research and scientific papers

Discovery and Biological Evaluation of N-Methyl-pyrrolo[2,3- b]pyridine-5-carboxamide Derivatives as JAK1-Selective Inhibitors

Janus kinase 1 (JAK1) plays a key role in most cytokine-mediated inflammatory and autoimmune responses through JAK/STAT signaling; thus, JAK1 inhibition is a promising therapeutic strategy for several diseases. Analysis of the binding modes of current JAK inhibitors to JAK isoforms allowed the design of N-alkyl-substituted 1-H-pyrrolo[2,3-b] pyridine carboxamide as a JAK1-selective scaffold, and the synthesis of various methyl amide derivatives provided 4-((cis-1-(4-chlorobenzyl)-2-methylpiperidin-4-yl)amino)-N-methyl-1H-pyrrolo[2,3-b]pyridine-5-carboxamide (31g) as a potent JAK1-selective inhibitor. In particular, the (S,S)-enantiomer of 31g (38a) exhibited excellent potency for JAK1 and selectivity over JAK2, JAK3, and TYK2. On investigating the effect of 31g on hepatic fibrosis, it was found that it reduces the proliferation and fibrogenic gene expression of TGF-β-induced hepatic stellate cells (HSCs). Specifically, 31g significantly inhibited TGF-β-induced migration of HSCs at 0.25 μM in wound-healing assays.

NAPHTHALENYLOXYPROPENYL DERIVATIVES HAVING INHIBITORY ACTIVITY AGAINST HISTONE DEACETYLASE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

The present invention discloses novel naphthalenyloxypropenyl derivatives useful for inhibiting the enzyme activity of histone deacetylase, leading effective suppression of cancer cell proliferation

ALKYLCARBAMOYL NAPHTHALENYLOXY- OCTENOYLHYDROXYAMIDE DERIVATIVES HAVING INHIBITORY ACTIVITY AGAINST HISTONE DEACETYLASE AND PREPARATION THEREOF

This invention discloses a novel alkylcarbamoyl naphthalenyloxy octenoylhydroxyamide derivative of formula (1) useful for inhibiting the enzyme activity of histone deacetylase, which leads to effective suppression of the cancer cell proliferation, a method for preparing same and a pharmaceutical composition comprising same.

Naphthyridine antibacterial agents

Novel naphthyridine-carboxylic acids as antibacterial agents are described as well as methods for their manufacture, formulation, and use in treating bacterial infections.

Process for the synthesis of 3-chloro-2,4,5-trifluorobenzoic acid

An improved process for the preparation of 3-chloro-2,4,5-trifluorobenzoic acid is described which involves reaction of a diester of 3,4,5,6-tetrafluoro-1,2-benzenedicarboxylic acid with a substituted amine to afford 3-amino-2,4,5-trifluorobenzoic acid followed by subsequent conversion of the amio intermediate into 3-chloro-2,4,5-trifluorobenzoic acid.

Antibacterial agents

Novel quinoline-carboxylic acids as antibacterial agents are described as well as methods for their manufacture, formulation, and use in treating bacterial infections including the description of certain novel intermediates used in the manufacture of the antibacterial agents.

Antibacterial agents

Novel naphthyridine-, quinoline- and benzoxazine-carboxylic acids as antibacterial agents are described as well as methods for their manufacture, formulation, and use in treating bacterial infections including the description of certain novel intermediates used in the manufacture of the antibacterial agents.

7-substituted amino-1-aryl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids and derivatives thereof as antibacterial agents

Novel 1-aryl or heteroaryl-6,8-difluoro-1,4-dihydro-7-(3-aminomethyl)pyrrolidinyl- or 7-spiroamino-4-oxo-3-quinolinecarboxylic acids and acid derivatives thereof as antibacterial agents are described as well as methods for their manufacture, formulation a

Antibacterial agents III

Novel 1-amino-naphthyridine- and quinoline-carboxylic acids as antibacterial agents are described as well as methods for their manufacture, formulation, and use in treating bacterial infections.