99758-86-8Relevant academic research and scientific papers
Cycloalkane and alicyclic heterocycle complexation by new switchable resorcin[4]arene-based container molecules: NMR and ITC binding studies
Hornung, Jens,Fankhauser, Daniel,Shirtcliff, Laura D.,Praetorius, Antonia,Schweizer, W. Bernd,Diederich, Francois
supporting information; experimental part, p. 12362 - 12371 (2011/12/15)
The synthesis and structural characterization of novel, "molecular basket"-type bridged cavitands is reported. The resorcin[4]arene-based container molecules feature well-defined cavities that bind a wide variety of cycloalkanes and alicyclic heterocycles
Novel anti-Markovnikov regioselectivity in the Wacker reaction of styrenes
Wright, Joseph A.,Gaunt, Matthew J.,Spencer, Jonathan B.
, p. 949 - 955 (2007/10/03)
The Wacker reaction is one of the longest known palladium-catalysed organic transformations, and in the vast majority of cases proceeds with Markovnikov regioselectivity. Palladium(II)-mediated oxidation of styrenes was examined and in the absence of reoxidants was found to proceed in an anti-Markovnikov sense, giving aldehydes. Studies on the mechanism of this unusual transformation were carried out, and indicate the possible involvement of a η4-palladium-styrene complex. With a heteropolyacid as the terminal oxidant, oxidation of styrene to give the anti-Markovnikov aldehyde as the major product was found to be catalytic.
Functionalized and Partially or Differentially Bridged Resorcin[4]arene Cavitands: Synthesis and Solid-State Structures
Azov, Vladimir A.,Skinner, Philip J.,Yamakoshi, Yoko,Seiler, Paul,Gramlich, Volker,Diederich, Francois
, p. 3648 - 3670 (2007/10/03)
We report the synthesis and structural characterization of modified Cram-type, resorcin[4]arene-based cavitands. Two main loci on the cavitand backbone were selected for structural modification: the upper part (wall domain) and the lower part (legs). Synthesis of unsymmetrically bridged cavitands with different wall components (i.e., 7, 8, and 14-18) was performed by stepwise bridging of the four couples of neighboring, H-bonded OH-groups of octol la (Schemes 1, 2, 4, and 5). Cavitands with modified legs (i.e., 20, 24, 27, and 28), targeted for surface immobilization, were synthesized by short routes starting from suitable aldehyde starting materials incorporating either the fully preformed leg moieties or functional precursors to the final legs (Schemes 7-10). The new cavitand substitution patterns described in this paper should enable the construction of a wide variety of functional architectures in the future. X-Ray crystallography afforded the characterization of cavitands 2c (Fig. 3) and 24 (Fig. 7) in the vase conformation, with 2c featuring a well-ordered CH2Cl2 guest molecule in its cavity. A particular highlight is the X-ray crystal-structure determination of octanitro derivative 19 (Scheme 6), which, for the first time, shows a cavitand, lacking substituents in the ortho-position to the two O-atoms of the four resorcinol moieties, in the kite-conformation (Fig. 5).
DERIVATIVES OF AROMATIC CYCLIC ALKYLETHERS
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, (2008/06/13)
The present invention provides compounds of the formula: and the pharmaceutically acceptable salts thereof, wherein: R1 and R2 are each alkyl; n is an integer of from 1 to 4; x is oxygen or -(CH2)m-; m is an integer of from 1 to 3; y is oxygen or sulfur; and p is an integer of from 1 to 4. These compounds are inhibitors of COX-I and/or COX-II, and are useful for the treatment of inflammation-associated disorders. The present invention also provides pharmaceutical compositions comprising a therapeutically-effective amount of a compound of Formula I in combination with a pharmaceutically-acceptable carrier, and a method for treating inflammation-associated disorders in an animal comprising administering a therapeutically-effective amount of a compound of Formula I to the animal
