99779-30-3

Upstream product

• 52537-88-9 N-(2-hydroxybenzyl)-p-anisidine 
• 79-04-9 chloroacetyl chloride 
• 889-08-7 (E)-2-(((4-methoxyphenyl)imino)methyl)phenol 
• 104-94-9 4-methoxy-aniline 
• 89-95-2 2-methyl-benzyl alcohol 

Downstream Products

• 1222170-20-8 4-(4-methoxyphenyl)-4,5-dihydrobenzo[f][1,4]oxazepin-3(2H)-thione 

Relevant academic research and scientific papers

Synthesis and structure-antibacterial activity relationship studies of 4-substituted phenyl-4,5-dihydrobenzo[f][1,4]oxazepin-3(2H)-thiones

The synthesis and characterization of a series of 4-substituted phenyl-4,5-dihydrobenzo[f][1,4]oxazepin- 3(2H)-thiones were presented. Preliminary in vitro antimicrobial activity of the compounds was assessed against a panel of microorganisms including S.

Synthesis of substituted 1,4-benzoxazepin-3-one derivatives

A synthesis of substituted 1,4-benzoxazepin-3-one is described starting from salicylaldehyde, aniline and chloroacetyl chloride. Use of 2-bromo-3-phenylpropionyl chloride gave access to 2-benzyl-1,4-benzoxazepin-3-one; an addition/elimination sequence afforded the corresponding benzylidene derivative which structure has been confirmed by an X-Ray analysis. Biphenyl substituents were also introduced in position -4 of this scaffold.