99802-77-4

Upstream product

• 109-72-8 n-butyllithium 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 148990-12-9 2,4-ditriflyloxy-6-methylpyrimidine 
• 874-90-8 4-methoxybenzonitrile 
• 67-64-1 acetone 
• 5424-21-5 2,4-dichloro-6-methylpyrimidine 
• 5720-07-0 4-methoxyphenylboronic acid 
• 82303-13-7 (4-methoxyphenyl)zinc(II) bromide 

Downstream Products

• 890137-58-3 4-bromomethyl-2,6-bis-(4-methoxy-phenyl)-pyrimidine 
• 908831-28-7 {4-[2,6-bis-(4-methoxy-phenyl)-pyrimidin-4-ylmethoxy]-2-methyl-phenoxy}-acetic acid methyl ester 

Relevant academic research and scientific papers

1,3,5-Trisubstituted aryls as highly selective PPARδ agonists

A series of highly potent and selective PPARδ agonists is described using the known non-selective ligand GW2433 as a structural template. Compound 1 is bioavailable, potent (10 nM), and shows no cross-activity with other PPAR subtypes up to 10 μM, making it a useful tool in studying the biological effects of selective PPARδ activation.

REGIOSELECTIVE SUBSTITUTION IN TRIFLYLOXYPYRIMIDINES AND CHLOROPYRIMIDINES USING ZINC AND TIN REAGENTS

2,4-Ditriflyloxy-6-methylpyrimidine has been synthesized and its ability to undergo palladium catalysed coupling with both zinc and tin reagents studied.Similar coupling reactions with 2,4-dichloropyrimidine establish triflyloxypyrimidines as being more r

PREPARATION OF PYRIMIDINES AND PYRIDINES FROM ALKYL KETONES AND NITRILES IN PRESENCE OF PHOSPHORYL CHLORIDE

The reaction of alkyl ketones with nitriles in the presence of POCl3 has been examined.It has been found that N-vinylimidoyl dichlorophosphates initially formed react further with excess nitriles or ketones to afford pyrimidine or pyridine derivatives, respectively.