99807-54-2

Basic information

• Product Name: 2-(4-bromomethylphenyl)propionic acid methyl ester
• Synonyms: 2-(4-bromomethylphenyl)propionic acid methyl ester
• CAS NO: 99807-54-2
• Molecular Weight: 257.127
• Mol File: 99807-54-2.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 298.6±20.0 °C(Predicted)
• Density: 1.360±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 2-(4-bromomethylphenyl)propionic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-bromomethylphenyl)propionic acid methyl ester(99807-54-2)
• EPA Substance Registry System: 2-(4-bromomethylphenyl)propionic acid methyl ester(99807-54-2)

Safety Data

• Hazardous Substances Data: 99807-54-2(Hazardous Substances Data)

Usage

Uses

4-(Bromomethyl)-α-methyl-benzeneacetic Acid Methyl Ester is a useful reagent for organic synthesis.

Upstream product

• 79443-97-3 methyl 2-(4-methylphenyl)propanoate 
• 938-94-3 (R,S)-2-(4'-methylphenyl) propionic acid 
• 2362-36-9 1-(1-chloroethyl)-4-methylbenzene 
• 67-56-1 methanol 
• 111128-12-2 2-[4-(bromomethyl)phenyl]propanoic acid 

Downstream Products

• 63476-54-0 2-(4-formylphenyl)propionic acid methyl ester 
• 81762-92-7 loxoprofen methyl ester 
• 80382-23-6 sodium 2-<4-<(2-oxocyclopentyl)methyl>phenyl>propionate 
• 68767-14-6 loxoprofen 
• 1012311-88-4 Methyl 2-[4-(3-cyano-4-oxothiolan-3-ylmethyl)phenyl]propionate 

Relevant articles and documents

Preparation process of pebiprofen

The invention belongs to the field of chemistry, and particularly relates to a novel process for preparing a phenylpropionic acid non-steroidal anti-inflammatory drug pebiprofen. According to the invention, 2-(4-bromomethyl phenyl) propionic acid which is easy to obtain is used as a starting raw material, and the product is prepared by four steps of esterification, hydroformylation, condensation and hydrolysis reaction. The method has the characteristics of simplicity in operation, high reaction selectivity, few byproducts and high product quality.

New method for synthesizing loxoprofen sodium

The invention belongs to the field of synthesis of organic matters and specifically relates to a new method for synthesizing loxoprofen sodium. The synthesis method is characterized by taking 2-(4-bromomethyl) phenylpropionic acid as a raw material and performing a 4-step reaction to prepare the loxoprofen sodium. The new method for synthesizing the loxoprofen sodium adopted by the invention has the effects that the yield is increased and the industrial prospect is good.

2-(4'-bromomethylphenyl)propionate synthesis method

The invention discloses a 2-(4'-bromomethylphenyl)propionate synthesis method. In the prior art, the catalyst must be used in the existing synthesis process so as to cause various side reactions. A purpose of the present invention is to solve the problem in the prior art. The technical scheme comprises: carrying out mixed dissolving on 2-(4'-bromomethylphenyl)propionic acid, methanol or ethanol and a solvent, carrying out a heating reflux reaction, carrying out a fractionation reaction, carrying out pressure reducing distillation, and separating to obtain the unreacted methanol or ethanol, theunreacted solvent, and the product 2-(4'-bromomethylphenyl)methyl propionate or 2-(4'-bromomethylphenyl)ethyl propionate. According to the present invention, the method has advantages of simple process, simple raw material, no addition of additives, mild reaction, no side reaction, short reaction time, high yield, effectively reduced production cost, effectively reduced equipment investment and environment protection.