99807-54-2

Usage

Uses

Used in Organic Synthesis:
2-(4-bromomethylphenyl)propionic acid methyl ester is used as a reagent for organic synthesis due to its unique structure and functional groups, which can be utilized in the preparation of various organic compounds and pharmaceuticals. Its bromomethyl group allows for further functionalization and modification, making it a versatile building block in the synthesis of complex organic molecules.

Upstream product

• 79443-97-3 methyl 2-(4-methylphenyl)propanoate 
• 67-56-1 methanol 
• 111128-12-2 2-[4-(bromomethyl)phenyl]propanoic acid 
• 938-94-3 (R,S)-2-(4'-methylphenyl) propionic acid 
• 2362-36-9 1-(1-chloroethyl)-4-methylbenzene 

Downstream Products

• 63476-54-0 2-(4-formylphenyl)propionic acid methyl ester 
• 81762-92-7 loxoprofen methyl ester 
• 80382-23-6 sodium 2-<4-<(2-oxocyclopentyl)methyl>phenyl>propionate 
• 68767-14-6 loxoprofen 
• 1012311-88-4 Methyl 2-[4-(3-cyano-4-oxothiolan-3-ylmethyl)phenyl]propionate 

Relevant academic research and scientific papers

Preparation process of pebiprofen

The invention belongs to the field of chemistry, and particularly relates to a novel process for preparing a phenylpropionic acid non-steroidal anti-inflammatory drug pebiprofen. According to the invention, 2-(4-bromomethyl phenyl) propionic acid which is easy to obtain is used as a starting raw material, and the product is prepared by four steps of esterification, hydroformylation, condensation and hydrolysis reaction. The method has the characteristics of simplicity in operation, high reaction selectivity, few byproducts and high product quality.

Loxoprofen derivative

The invention provides a Loxoprofen derivative shown in the following formula (I). R1 is hydrogen atoms or substituted or non-substituted alkyl, R2 is substituted or non-substituted alkyl, the Loxoprofen derivative has low gastrointestinal tract side effects, and the bioavailability can be improved. The formula (I) is shown in the specification.

New method for synthesizing loxoprofen sodium

The invention belongs to the field of synthesis of organic matters and specifically relates to a new method for synthesizing loxoprofen sodium. The synthesis method is characterized by taking 2-(4-bromomethyl) phenylpropionic acid as a raw material and performing a 4-step reaction to prepare the loxoprofen sodium. The new method for synthesizing the loxoprofen sodium adopted by the invention has the effects that the yield is increased and the industrial prospect is good.

Synthesis method of loxoprofen sodium

The invention discloses a synthesis method of loxoprofen sodium, which comprises the following steps of: step 1), preparing N-(1-cyclopentenyl) morpholine; step 2), preparing 2-(4-bromomethyl phenyl)methyl propionate, the method also comprises the following step 3), preparing loxoprofen sodium by an enamine alkylation method: first dissolving 2-(4-bromomethyl phenyl) methyl propionate in a solvent, adding N-(1-cyclopentenyl) morpholine and the solvent in a container, dropwise adding 2-(4-bromomethyl phenyl) methyl propionate solution under reflux conditions; continuing reacting under reflux conditions after the completion of the dropwise addition; adding alkali solution after obtained reaction liquid is cooled, hydrolysising and separating to obtain an organic phase and an aqueous phase respectively, extracting the aqueous phase with an extractant to obtain extract liquid and the aqueous phase after extraction respectively, and post-treating the aqueous phase after extraction to obtain loxoprofen sodium. The preparation of loxoprofen sodium by the above method has the advantages of simple reaction steps, high yield of loxoprofen sodium and low production cost.

2-(4'-bromomethylphenyl)propionate synthesis method

The invention discloses a 2-(4'-bromomethylphenyl)propionate synthesis method. In the prior art, the catalyst must be used in the existing synthesis process so as to cause various side reactions. A purpose of the present invention is to solve the problem in the prior art. The technical scheme comprises: carrying out mixed dissolving on 2-(4'-bromomethylphenyl)propionic acid, methanol or ethanol and a solvent, carrying out a heating reflux reaction, carrying out a fractionation reaction, carrying out pressure reducing distillation, and separating to obtain the unreacted methanol or ethanol, theunreacted solvent, and the product 2-(4'-bromomethylphenyl)methyl propionate or 2-(4'-bromomethylphenyl)ethyl propionate. According to the present invention, the method has advantages of simple process, simple raw material, no addition of additives, mild reaction, no side reaction, short reaction time, high yield, effectively reduced production cost, effectively reduced equipment investment and environment protection.

Method for synthesizing high-purity non-steroidal anti-inflammatory drug loxoprofen sodium

The invention discloses a method for synthesizing high-purity non-steroidal anti-inflammatory drug loxoprofen sodium, 2-(4-bromomethylphenyl) methyl propionate b is synthesized by esterification of raw material a and methanol, intermediate compound c and loxoprofen acid are synthesize sequentially, and the loxoprofen sodium is finally synthesized. The reaction mechanism is simple, by-products arefew, synthesis steps are easy to control, the raw material is easily available, and the impurity content of each step is strictly controlled. The purifying method is easy to operate and suitable for industrial production. The white flake crystal loxoprofen sodium is prepared. Finally, HPLC analysis shows that the loxoprofen sodium content detected by HPLC is as high as 99.95%.

Method for preparing loxoprofen sodium

The invention relates to the technical field of organic synthesis, in particular to a method for preparing loxoprofen sodium. The invention provides a compound with the structure shown in formula 5 and a preparation method and application of the compound, (the formula is defined in the description). The loxoprofen sodium obtained according to the scheme is high in purity, high in industrialized operation, and good in application prospect.

A New Versatile Water-Soluble Iniferter Platform for the Preparation of Molecularly Imprinted Nanoparticles by Photopolymerisation in Aqueous Media

The multi-step synthesis of a new water-soluble dithiocarbamate iniferter platform for the preparation of nanoparticles and -gels in aqueous solvents by photoinduced living-radical polymerisation is described herein. The water solubility of the dithiocarb

SPIRO IMIDAZOLE DERIVATIVES AS PPAR MODULATORS

The invention provides compounds (Ia), (Ib) and (Ic), pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of the Peroxisome Proliferator-Activated

NOVEL ADENINE COMPOUND AND USE THEREOF

A drug for topically administration which is effective as an antiallergic agent. The drug for topically administration contains as an active ingredient an adenine compound represented by the general formula (1): [wherein ring A represents a 6 to 10 membered, mono or bicyclic, aromatic hydrocarbon or a 5 to 10 membered, mono or bicyclic, aromatic heterocycle containing one to three heteroatoms selected among 0 to 2 nitrogen atoms, 0 or 1 oxygen atom, and 0 or 1 sulfur atom; n is an integer of 0 to 2; m is an integer of 0 to 2; R represents halogeno, (un)substituted alkyl, etc.; X1 represents oxygen, sulfur, NR1 (R1 represents hydrogen or alkyl), or a single bond; Y1 represents a single bond, alkylene; etc.; Y2 represents a single bond, alkylene, etc.; Z represents alkylene; and at least one of Q1 and Q2 represents -COOR10 (wherein R10 represents (un)substituted alkyl, etc.), etc.] or a pharmaceutically acceptable salt of the compound.