63476-54-0

Usage

Structure

An ester derivative of 2-(4-formylphenyl)propionic acid

Common uses

Intermediate in the synthesis of pharmaceutical compounds and organic materials, development of anti-inflammatory drugs, production of fragrances and flavors

Physical properties

Colorless to pale yellow liquid, fruity odor

Importance

Versatile reactivity and functional group compatibility in organic synthesis

Upstream product

• 554-12-1 propanoic acid methyl ester 
• 100-52-7 benzaldehyde 
• 2362-36-9 1-(1-chloroethyl)-4-methylbenzene 
• 938-94-3 (R,S)-2-(4'-methylphenyl) propionic acid 
• 111128-12-2 2-[4-(bromomethyl)phenyl]propanoic acid 
• 99807-54-2 2-(4-bromomethylphenyl)propionic acid methyl ester 
• 79443-97-3 methyl 2-(4-methylphenyl)propanoate 

Downstream Products

• 63476-37-9 2-[4-(3-Methyl-5-oxo-cyclohex-3-enyl)-phenyl]-propionic acid 
• 63476-38-0 2-[4-(3-Hydroxy-5-methyl-cyclohexyl)-phenyl]-propionic acid 
• 81762-92-7 loxoprofen methyl ester 
• 80382-23-6 sodium 2-<4-<(2-oxocyclopentyl)methyl>phenyl>propionate 

Relevant academic research and scientific papers

Metal- And additive-free C-H oxygenation of alkylarenes by visible-light photoredox catalysis

A metal- and additive-free methodology for the highly selective, photocatalyzed C-H oxygenation of alkylarenes under air to the corresponding carbonyls is presented. The process is catalyzed by an imide-acridinium that forms an extremely strong photooxidant upon visible light irradiation, which is able to activate inert alkylarenes such as toluene. Hence, this is an easy to perform, sustainable and environmentally friendly oxidation that provides valuable carbonyls from abundant, readily available compounds.

Preparation process of pebiprofen

The invention belongs to the field of chemistry, and particularly relates to a novel process for preparing a phenylpropionic acid non-steroidal anti-inflammatory drug pebiprofen. According to the invention, 2-(4-bromomethyl phenyl) propionic acid which is easy to obtain is used as a starting raw material, and the product is prepared by four steps of esterification, hydroformylation, condensation and hydrolysis reaction. The method has the characteristics of simplicity in operation, high reaction selectivity, few byproducts and high product quality.

Method for preparing loxoprofen sodium

The invention relates to the technical field of organic synthesis, in particular to a method for preparing loxoprofen sodium. The invention provides a compound with the structure shown in formula 5 and a preparation method and application of the compound, (the formula is defined in the description). The loxoprofen sodium obtained according to the scheme is high in purity, high in industrialized operation, and good in application prospect.

Conjugate addition of lithium enolates to aromatic carbonyl compounds complexed with aluminum tris(2, 6-diphenylphenoxide) (ATPH)

Various lithium enolates of esters undergo effective 1, 6-addition to aromatic carbonyl compounds in the presence of aluminum tris(2, 6-diphenylphenoxide)(ATPH). Thieme.