99822-84-1Relevant academic research and scientific papers
Novel quinuclidinyl heteroarylcarbamate derivatives as muscarinic receptor antagonists
Nagashima, Shinya,Matsushima, Yuji,Hamaguchi, Hisao,Nagata, Hiroshi,Kontani, Toru,Moritomo, Ayako,Koshika, Tadatsura,Takeuchi, Makoto
, p. 3478 - 3487 (2014/06/23)
Herein, we describe the synthesis and pharmacological profiles of novel quinuclidinyl heteroarylcarbamate derivatives. Among them, the quinuclidin-4-yl thiazolylcarbamate derivative ASP9133 was identified as a promising long-acting muscarinic antagonist (LAMA) showing more selective inhibition of bronchoconstriction against salivation and more rapid onset of action in a rat model than tiotropium bromide.
THIAZOLYL-AND OXAZOLYL-ISOQUINOLINONES AND METHODS FOR USING THEM
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Page/Page column 10, (2009/12/28)
The present invention relates to substituted thiazolyl- and oxazoyl-isoquinolinones that act, for example, as modulators of poly(ADP-ribose) polymerase (PARP). The present invention also relates to processes for the preparation of substituted thiazolyl- a
