99855-42-2

Upstream product

• 62750-11-2 ethyl 3-phenylaminopropionate 
• 62-53-3 aniline 
• 67491-39-8 N-(3,3-dichloro-allyl)-aniline 
• 5652-38-0 N-phenyl-β-alanine 
• 21911-84-2 methyl 3-(phenylamino)propanoate 
• 75-36-5 acetyl chloride 
• 99854-35-0 N-(3,3-dichloro-allyl)-acetanilide 

Downstream Products

• 1732-09-8 dimethyl subarate 
• 120167-87-5 N,N'-butanediyl-bis-acetanilide 
• 120167-86-4 6-(Acetyl-phenyl-amino)-hexanoic acid methyl ester 

Relevant academic research and scientific papers

Exploring the Conformation of Mixed Cis- Trans α,β-Oligopeptoids: A Joint Experimental and Computational Study

The synthesis and conformational preferences of a set of new synthetic foldamers that combine both the α,β-peptoid backbone and side chains that alternately promote cis- and trans-amide bond geometries have been achieved and addressed jointly by experiment and molecular modeling. Four sequence patterns were thus designed and referred to as cis-β-trans-α, cis-α-trans-β, trans-β-cis-α, and trans-α-cis-β. α- and βNtBu monomers were used to enforce cis-amide bond geometries and α- and βNPh monomers to promote trans-amides. NOESY and molecular modeling reveal that the trans-α-cis-β and cis-β-trans-α tetramers show a similar pattern of intramolecular weak interactions. The same holds for the cis-α-trans-β and trans-β-cis-α tetramers, but the interactions are different in nature than those identified in the trans-α-cis-β-based oligomers. Interestingly, the trans-α-cis-β peptoid architecture allows establishment of a larger amount of structure-stabilizing intramolecular interactions.

With anti-HIV active 3 - amino propionic acid piperidine amide compound, synthetic method and use

The invention relates to a 3-aminopropionic acid piperidine amide compound as shown in formula I, and its pharmaceutically acceptable salts or solvates, wherein the substituents are defined in claims; the invention also relates to a preparation method of the compound, pharmaceutical compositions containing the compound, the salts or solvates, and applications in preparation of drugs for treating HIV infection related diseases and symptoms.

Syntheses d'amidoesters par reaction de Kolbe

The synthesis of amidoesters has been investigated by anodic cooxidation of diacid hemiesters CO2H-CH2-Z-CO2CH3 -CH2-> and amidoacids R1-N(Y)-(CH2)2-CO2H .The scope of this reaction was examined in detail.This synthetic pathway provided very a simple access to a wide range of amidoesters R1-N(Y)-(CH2)3-Z-CO2CH3 by varying Z and R1 as well as n value.