99873-50-4Relevant academic research and scientific papers
Synthesis and biological evaluation of 4-arylcoumarins as potential anti-Alzheimer's disease agents
Miao, Yuhang,Sun, Jie,Wang, Xiaojing,Yang, Jie,Yun, Yinling
, (2020/01/03)
Alzheimer's disease (AD) is a progressive neurological degenerative disease that has complex pathogenesis. A variety of studies in humans indicate that several enzymes inhibitors can be useful in the treatment of AD, including acetylcholinesterase (AchE), butyrylcholinesterase (BuChE) and monoamine oxidase (MAO). Various substituted 4-arylcoumarin derivatives were synthesised, and their activity in vitro were investigated, including AChE/BuChE inhibitory activity, MAO inhibitory activity, and antioxidant activity. Most of the compounds were found to exhibit high inhibitory activity, and individual compounds have extremely excellent activities. Therefore 4-arylcoumarins provides an idea for drugs design for the development of therapeutic or preventive agents for AD.
Synthesis and biological evaluation of novel neoflavonoid derivatives as potential antidiabetic agents
Wang, Bing,Li, Na,Liu, Teng,Sun, Jie,Wang, Xiaojing
, p. 34448 - 34460 (2017/07/22)
Various substituted neoflavonoid derivatives were synthesized using sulfated montmorillonite K-10 as a catalyst. This method is environmental friendly, sustainable and economical, convenient in isolation and purification processes, with little byproducts, using earth-abundant catalysts and has relatively high yield. Those neoflavonoid derivatives were screened for antioxidant, a-glucosidase inhibitory, aldose reductase 2 (ALR2) inhibitory and advanced glycation end-product formation inhibitory effects. Most compounds exhibited significant antioxidant and advanced glycation end-product (AGE) formation inhibitory activities. It was interesting to note that out of thirty compounds, 8k and 8l were found to have greater ALR2 inhibitory activity than the standard drug quercetin. The pharmacological studies suggested neoflavonoid with adjacent 7,8-dihydroxy groups were more effective in inhibiting ALR2. Antidiabetic activity studies had shown that compounds 8l and 8m were equipotent to the standard drug glibenclamide in vivo. In summary, the target compound 8l provided a potential drug design concept for the development of therapeutic or prophylactic agents of diabetes and diabetes complications.
An efficient synthesis of neoflavonoid antioxidants based on Montmorillonite K-10 catalysis
Lee,Tseng,Lee
, p. 2247 - 2254 (2007/10/03)
A new approach to synthesis of neoflavonoids, based on a high yielding Montmorillonite K-10 catalyzed lactone ring forming cyclization process, is described. The utility of this methodology is exemplified by its employment in the preparation of the substituted 4-phenylneoflavonoids 1-8. The free radical scavenging properties of these substances were evaluated. The neoflavonoids 1 and 5, which mimic esculetin-type antioxidants, were observed to quench hydrazyl free radicals.
An efficient bromination of alkenes using cerium(IV) ammonium nitrate (CAN) and potassium bromide
Nair, Vijay,Panicker, Sreeletha B,Augustine, Anu,George, Tesmol G,Thomas, Siji,Vairamani
, p. 7417 - 7422 (2007/10/03)
Bromination of alkenes using a combination of potassium bromide and cerium(iv) ammonium nitrate (CAN) in a two phase system consisting of water and dichloromethane affords the corresponding dibromides in excellent yield. The reaction most likely involves the addition of the bromine radical generated from bromide ion by CAN and subsequent formation of the dibromide.
Enolethers and their use as a fungicide
-
, (2008/06/13)
Enolethers and thioenolethers of formula I STR1 are disclosed. The compounds are useful for combatting phytopathogenic fungi.
